表观遗传修饰参与糖尿病视网膜病变代谢记忆的研究进展  

Research progress on epigenetic modification involved in metabolic memory of diabetic retinopathy

作　　者：骞元婕 魏雁涛[1] Yuan-Jie Qian;Yan-Tao Wei(Zhongshan Ophthalmic Center,Sun Yat-sen University,State Key Laboratory of Ophthalmology,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangdong Provincial Clinical Research Center for Ocular Diseases,Guangzhou 510060ꎬGuangdong Province,China)

机构地区：[1]中山大学中山眼科中心眼科学国家重点实验室广东省眼科视觉科学重点实验室广东省眼部疾病临床医学研究中心,广东省广州市510060

出　　处：《国际眼科杂志》2022年第10期1634-1637,共4页International Eye Science

基　　金：国家自然科学基金资助项目(No.81570865)。

摘　　要：糖尿病视网膜病变(DR)在血糖控制良好的情况下仍可能持续并进展,这表明先前的高血糖会导致长期有害的血管功能障碍,这种现象被定义为糖尿病视网膜病变的“代谢记忆”(metabolic memory)。糖尿病视网膜病变起病隐匿,目前的治疗方式主要为临床对症治疗,缺乏有效早期诊断、精准治疗和判断预后的手段,新的诊治思路亟待开发。近年来许多新兴研究证明表观遗传修饰在DNA甲基化、组蛋白翻译后修饰和微小RNA(microRNAs,miRNAs)调控等方面参与了糖尿病视网膜病变“代谢记忆”的发病机制,为糖尿病视网膜病变分子机制的探究提供了努力方向和研究策略。本文综述了表观遗传修饰在糖尿病视网膜病变发病机制中的作用,潜在挑战和治疗前景,旨在为未来早期诊断和治疗糖尿病视网膜病变提供参考。Diabetes retinopathy(DR)may continue to develop even if blood sugar is well controlled,which indicates that previous hyperglycemia will lead to long-term harmful vascular dysfunction,and this phenomenon is defined as“metabolic memory”of diabetes retinopathy.Because the onset of DR is insidious,clinical symptomatic treatment is mainly used.Effective means of early diagnosis,accurate treatment and prognosis are lacking and new diagnosis and treatment ideas need to be developed urgently.In recent years,many new studies have shown that epigenetic modification is involved in the pathogenesis of DR“metabolic memory”in DNA methylation,histone post-translational modification and microRNA(microRNAs,miRNAs)regulation,which provides a direction and strategy for the exploration of DR molecular mechanism.In this review,we discussed the role of epigenetic modification in the pathogenesis of DR and analyzed the challenges and prospects of its application in the treatment of DR,with a view to provide a reference for early diagnosis and treatment of DR in the future.

关 键 词：糖尿病视网膜病变 代谢记忆 表观遗传修饰 综述 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]