达格列净联合益生菌治疗对糖尿病肾脏病患者炎症指标、血糖及肾功能的影响  

Effects of Dapagliflozin Combined with Probiotics Therapy on Inflammatory Indexes,Blood Glucose and Renal Function in Patients with Diabetic Nephropathy

作　　者：管红斌[1] 吕路[1] 何凯平[2] 李峻[3] GUAN Hongbin;LYU Lu;HE Kaiping;LI Jun(Department of Nephrology,The First Affiliated Hospital of Guangdong Pharmaceutical University,Guangzhou,Guangdong Province,510080 China;Department of Medical Record Statistics,The First Affiliated Hospital of Guang-dong Pharmaceutical University,Guangzhou,Guangdong Province,510080 China;Outpatient Department of the First Affiliated Hospital of Guangdong Pharmaceutical University,Guangzhou,Guangdong Province,510080 China)

机构地区：[1]广东药科大学附属第一医院肾内科,广东广州510080 [2]广东药科大学附属第一医院病案统计科,广东广州510080 [3]广东药科大学附属第一医院门诊部,广东广州510080

出　　处：《糖尿病新世界》2022年第16期34-38,共5页Diabetes New World Magazine

摘　　要：目的探讨达格列净联合益生菌治疗对糖尿病肾脏病(diabetic kidney disease,DKD)患者炎症指标、血糖及肾功能的影响。方法选取2020年1月—2022年1月在广东药科大学附属第一医院肾内专科门诊就诊的DKD患者70例,采用随机数表随机分为对照组(n=35)和观察组(n=35),两照组均予以基础治疗,对照组给予达格列净治疗24周,观察组给予达格列净联合益生菌治疗24周。比较两组患者治疗前后的超敏C-反应蛋白(hs-CRP)、白介素-6(IL-6)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、血肌酐(SCr)、尿微量白蛋白/尿肌酐(UACR)的水平。结果治疗前,比较两组患者血清炎症指标、血糖控制、肾功能指标水平,差异无统计学意义(P>0.05)。治疗后,两组患者hs-CRP、IL-6、FPG、2 hPG、HbA1c、SCr、UACR水平较治疗前均明显下降,差异有统计学意义(P<0.05);且观察组hs-CRP、IL-6、FPG、2 hPG、HbA1c、SCr、UACR水平明显低于对照组,差异有统计学意义(P<0.05)。结论达格列净联合益生菌治疗能降低糖尿病肾脏病患者炎症反应,有效控制血糖和改善肾功能。Objective To investigate the effect of dapagliflozin combined with probiotics treatment on inflammatory indexes,blood sugar and renal function in patients with diabetic kidney disease(DKD).Methods A total of 70 patients with DKD who were admitted to the department of nephrology of the First Affiliated Hospital of Guangdong Pharmaceutical University from January 2020 to January 2022 were selected.The patients were randomly divided into the control group(n=35)and the observation group(n=35)using a random number table.Both two groups were given basic treatment,and the control group was given dapagliflozin treatment for 24 weeks.The observation group was given dapagliflozin combined with probiotics for 24 weeks.Comparison of high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1c)and serum creatinine(SCr),urinary microalbumin/urine creatinine(UACR)levels between the two groups before and after treatment.Results Before treatment,there was no statistically significant difference in the levels of serum inflammation indexes,blood glucose control and renal function indexes between the two groups(P>0.05).After treatment,the levels of hs-CRP,IL-6,FPG,2 hPG,HbA1c,SCr and UACR in the two groups were significantly decreased compared with those before treatment,the difference was statistically significant(P<0.05);hs-CRP,IL-6,FPG,2 hPG,HbA1c,SCr and UACR levels in the observation group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion Dapagliflozin combined with probiotics treatment can reduce the inflammatory response,effectively control blood glucose and improve renal function in patients with diabetic nephropathy.

关 键 词：达格列净 益生菌 糖尿病肾脏病 炎症指标 肾功能 

分 类 号：R587.2[医药卫生—内分泌]