血常规指标NLR、PLR、LMR联合用于糖尿病肾病诊断及进展评估的临床效果  

Clinical Effect of Combined Blood Routine Indexes NLR,PLR and LMR in the Diagnosis and Progression Assessment of Diabetic Nephropathy

作　　者：刘秀琴[1] 郭俊英[1] 周旭升[1] LIU Xiuqin;GUO Junying;ZHOU Xusheng(Affiliated Cancer Hospital of Fujian Medical University(Fujian Cancer Hospital),Fuzhou,Fujian Province,350014 China)

机构地区：[1]福建医科大学附属肿瘤医院(福建省肿瘤医院),福建福州350014

出　　处：《糖尿病新世界》2022年第16期50-53,共4页Diabetes New World Magazine

摘　　要：目的研究血常规指标中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、淋巴细胞/单核细胞比值(LMR)联合用于糖尿病肾病(diabetic kidney disease,DKD)诊断及进展评估的价值。方法选择2018年1月—2021年6月在福建医科大学附属肿瘤医院体检的2型糖尿病(type 2 diabetes,T2DM)患者,将尿微量白蛋白肌酐比(UACR)正常的87例患者纳入T2DM组、UACR30~300 mg/g的65例患者纳入DKD组,另取同期体检的80名健康者作为对照组,检测每组的NLR、PLR、LMR水平并对比分析。结果DKD组患者的NLR、PLR水平高于T2DM组、对照组,LMR水平低于T2DM组、对照组,差异有统计学意义(P<0.05);NLR、PLR、LMR的单独指标及Logistic回归方程的联合指标均对DKD具有诊断价值且联合指标的诊断效能优于单一指标;DKD组中白蛋白尿进展患者的NLR、PLR水平高于白蛋白尿未进展患者,LMR水平低于白蛋白尿未进展患者,差异有统计学意义(P<0.05)。结论血常规指标NLR、PLR、LMR联合使用能够为DKD的诊断及进展的评估提供依据。Objective To study the combination of blood routine indexes neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR)and lymphocyte/monocyte ratio(LMR)in the diagnosis and progress of diabetic nephropathy(DKD)assessed value.Methods Patients with type 2 diabetes mellitus(T2DM)who underwent a physical examination at the Affiliated Cancer Hospital of Fujian Medical University from January 2018 to June 2021 were selected,and 87patients with normal urinary albumin-to-creatinine ratio(UACR)were included in the T2DM group,UACR 30-300 mg/g65 of patients were included in the DKD group.Another 80 healthy people who underwent physical examination during the same period were selected as the control group,and the levels of NLR,PLR and LMR in each group were detected and compared and analyzed.Results The levels of NLR and PLR in the DKD group were higher than those in the T2DM group and the control group,and the LMR level was lower than that in the T2DM group and the control group,the difference was statistically significant(P<0.05).The individual indicators of NLR,PLR and LMR and the combined indicators of Logistic regression equation have diagnostic value for DKD,and the diagnostic performance of the combined indicators is better than that of a single indicator.In the DKD group,the levels of NLR and PLR in patients with progressive albuminuria were higher than those in patients with no progression of albuminuria,and the level of LMR was lower than those in patients with no progression of albuminuria,the difference was statistically significant(P<0.05).Conclusion The combined use of blood routine indicators NLR,PLR,and LMR can provide a basis for the diagnosis and progression of DKD.

关 键 词：血常规 2型糖尿病 糖尿病肾病 诊断 白蛋白尿进展 

分 类 号：R587.2[医药卫生—内分泌]