CXCL13在支气管哮喘患者的表达情况及其与IgE、EOS和肺功能的相关性  

Expression of CXCL13 in patients with bronchial asthma and its correlation with IgE,EOS and lung function

作　　者：王静[1] 苗姝[1] 佟金平[1] 王涛[2] 孙伟 WANG Jing;MIAO Shu;TONG Jingping;WANG Tao;SUN Wei(Department of Respiratory and Critical Care Medicine,Xinhua Hospital Affiliated to Dalian University,Dalian,Liaoning 116021,China;First Department of Respiratory and Critical Care Medicine,Zhongshan Hospital Affiliated to Dalian University,Dalian,Liaoning 116001,China;Department of Respiratory and Critical Care Medicine,Sichuan Academy of Medical Sciences·Sichuan Provincial People’s Hospital,Chengdu,Sichuan 610072,China)

机构地区：[1]大连大学附属新华医院呼吸与危重症医学科,辽宁大连116021 [2]大连大学附属中山医院呼吸与危重症医学一科,辽宁大连116001 [3]四川省医学科学院·四川省人民医院呼吸与危重症科,成都610072

出　　处：《重庆医学》2022年第18期3161-3165,共5页Chongqing medicine

基　　金：辽宁省大连市医学科学研究计划(1811114)。

摘　　要：目的探讨趋化因子配体13蛋白(CXCL13)水平与支气管哮喘中免疫球蛋白E(IgE)、嗜酸性粒细胞(EOS)及肺功能的相关性。方法选取2019年3月至2021年3月大连大学附属新华医院收治的100例支气管哮喘患者为研究对象,其中急性发作期60例(急性发作组)、慢性持续期40例(慢性持续组),另选取同期体检中心体检的40例健康志愿者作为健康对照组。所有研究对象均通过ELISA法及常规血生化检测血清CXCL13、IgE、EOS的表达水平,住院时间72 h内完善肺功能检查。根据CXCL13在急性发作期的表达水平,多元线性回归分析CXCL13与IgE、EOS和肺功能的相关性。受试者工作特征(ROC)曲线分析CXCL13、IgE、EOS对急性发作的预测效能。结果急性发作组CXCL13、IgE、EOS水平高于慢性持续组和健康对照组,且慢性持续组高于健康对照组,差异有统计学意义(P<0.05)。急性发作组第1秒用力呼气容积(FEV1)、第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)、第1秒用力呼气容积占预计值百分数(FEV1%pred)低于慢性持续组和健康对照组,且慢性持续组低于健康对照组,差异有统计学意义(P<0.05)。多元线性回归分析结果显示血清CXCL13与IgE、EOS呈正相关,与FEV1、FEV1/FVC、FEV1%pred呈负相关(P<0.05)。ROC曲线显示,CXCL13对预测急性发作的效能高于IgE、EOS。结论CXCL13可作为预测支气管哮喘急性发作的临床指标。Objective To explore the relationship between the level of C-X-C chemokine ligand 13(CXCL13)and eosinophils(EOS),immunoglobulin E(IGE)and lung function in bronchial asthma.Methods A total of 100 patients with bronchial asthma treated in this hospital from March 2019 to March 2021 were selected as the study subjects,including 60 cases of acute attack(the acute attack group)and 40 cases of chronic duration(the chronic duration group).In the same period,40 healthy volunteers who underwent the physical examination in the physical examination center of this hospital were selected as the healthy control group.ELISA and routine blood biochemistry were used to detect the expression levels of the serum CXCL13,IgE and EOS in study population.The pulmonary function examination was improved within 72 hours of hospitalization.According to the expression level of CXCL13 in acute attack,the multiple linear regression was used to analyze the correlation between CXCL13 and IgE,EOS and pulmonary function.The receiver operating characteristics(ROC)curve was used to analyze the predictive efficacy of CXCL13,IgE and EOS on the acute attack.Results The serum expression levels of CXCL13,IgE and EOS in the acute attack group were higher than those in the chronic duration group and the healthy control group,and the serum expression levels in the chronic duration group were higher than those in the healthy control group.The differences were statistically significant(P<0.05).The first second forced expiratory volume(FEV1),the ratio of first second forced expiratory volume to forced vital capacity(FEV1/FVC)and the percentage of first second forced expiratory volume in the predicted value(FEV1%pred)in the acute attack group were lower than those in the chronic duration group and the healthy control group,and the above indexes in the chronic duration group were lower than those in the healthy control group.The differences were statistically significant(P<0.05).Multiple linear regression analysis showed that serum CXCL13 was positively correla

关 键 词：支气管哮喘 趋化因子 趋化因子配体13蛋白 嗜酸性粒细胞 免疫球蛋白E 肺功能 

分 类 号：R562.25[医药卫生—呼吸系统]