适应性免疫在阿尔茨海默病中的作用  

Role of adaptive immunity in Alzheimer’s disease

作　　者：刘海萍 王斌[1] 张蓓[1] 万亿[1] 孙波 高明旭[1] 张丽(指导)[1] LIU Haiping;WANG Bin;ZHANG Bei;WAN Yi;SUN Bo;GAO Mingxu;ZHANG Li(School of Basic Medicine,Qingdao University,Qingdao 266071,China)

机构地区：[1]青岛大学基础医学院,青岛266071 [2]青岛市精神卫生中心,青岛266031

出　　处：《中国免疫学杂志》2022年第15期1913-1917,共5页Chinese Journal of Immunology

基　　金：山东省自然科学基金项目(ZR2021MH138);中国博士后科学基金项目(2016M592142)。

摘　　要：阿尔茨海默病(AD)是一种不可治愈的神经退行性疾病,是21世纪以来面临的一个巨大挑战。了解免疫系统参与对抗疾病至关重要。现综述对适应性免疫特别是T淋巴细胞在AD发病机制中的研究,初步证实以T淋巴细胞及其亚群、固有免疫细胞为主,通过与Aβ、Tau及HSV、EBV等自身/外源抗原发生免疫反应,未来亟需通过单细胞测序、BCR/TCR组库等高通量分析技术,及更多志愿者的CSF,整体研究AD炎症微环境的免疫应答、鉴定AD特异性抗原。这有助于确定新的靶标和治疗方案。Alzheimer’s disease(AD)is an incurable neurodegenerative disease,which is a great challenge in the 21st century.Understanding immunity is essential for combating in disease. Here we review recent findings in adaptive immune cells in AD,especially new dedication in T cells. Evidence shows T lymphocytes,their sub groups and innate immune cells are the main involved cells react with Aβ,Tau,HSV,EBV and other antigens in AD. In future,high-throughput analysis such as single-cell sequencing and BCR/TCR repertoire,and more CSF research are urgently needed for analysis the whole immune inflammatory response in AD. This could help identify new targets and treatment options.

关 键 词：阿尔茨海默病 适应性免疫应答 固有免疫应答 炎症 

分 类 号：R392.1[医药卫生—免疫学]