CCK、Cx43、GLP-1对2型糖尿病胃轻瘫患者胃排空的预测价值及其相关性分析  

Predictive value and correlation analysis of CCK,Cx43 and GLP-1 in gastric emptying in patients with type 2 diabetic gastroparesis

作　　者：张雪莲 王博 张玄娥 张晓燕 顾蕾 周尊海 ZHANG Xue-lian;WANG Bo;ZHANG Xuan-e;ZHANG Xiao-yan;GU Lei;ZHOU Zun-hai(Department of Endocrinology,Yangpu Hospital of Tongji University,Shanghai 200090,China)

机构地区：[1]同济大学附属杨浦医院内分泌科,上海200090

出　　处：《河北医科大学学报》2022年第9期1020-1024,共5页Journal of Hebei Medical University

基　　金：上海市自然科学基金(18ZR1435800)。

摘　　要：目的 探讨胆囊收缩素(cholecystokinin, CCK)、间隙连接蛋白43(connexin 43,Cx43)、胰高血糖素样肽1(glucagon-like peptide-1,GLP-1)对2型糖尿病胃轻瘫患者胃排空的预测价值及其相关性。方法 选择2型糖尿病胃功能异常患者127例,其中功能性消化不良49例设为消化不良组,糖尿病胃轻瘫患者78例设为胃轻瘫组,另选择同期体检的胃功能正常的健康者50例设为对照组,所有受试对象均进行胃半排空时间测定。酶联免疫吸附法检测CCK、Cx43、GLP-1水平,放射性核素法检测固体胃排空功能。分析CCK、Cx43、GLP-1对2型糖尿病胃轻瘫患者胃排空的预测价值,并分析CCK、Cx43、GLP-1的相关性。结果 消化不良组和胃轻瘫组CCK、Cx43水平低于对照组,GLP-1水平高于对照组,胃半排空时间长于对照组;胃轻瘫组CCK、Cx43水平低于消化不良组,GLP-1水平高于消化不良组,胃半排空时间长于消化不良组(P<0.05)。CCK、Cx43、GLP-1联合检测对2型糖尿病胃轻瘫患者胃排空的预测价值较高。CCK、Cx43呈正相关(r=0.482;P<0.001);CCK、GLP-1呈负相关(r=-0.356;P<0.001);Cx43、GLP-1呈负相关(r=-0.619;P<0.001)。结论 CCK、Cx43、GLP-1在2型糖尿病胃轻瘫疾病中异常表达,对预测2型糖尿病胃轻瘫患者有一定的价值。Objective To investigate the predictive value and correlation of cholecystokinin(CCK), connexin 43(Cx43) and glucagon-like peptide-1(GLP-1) in gastric emptying in patients with type 2 diabetic gastroparesis(DGP). Methods In total, 127 patients with type 2 diabetes with abnormal gastric function were selected, including 49 patients with functional dyspepsia as dyspepsia group, and 78 patients with diabetic gastroparesis as gastroparesis group. Another 50 healthy patients with normal gastric function who underwent physical examination during the same period were selected as control group. The gastric half-emptying time was measured in all subjects. CCK, Cx43 and GLP-1 levels were detected by enzyme-linked immunosorbent assay, and solid gastric emptying ability was detected by radionuclide. The predictive value of CCK, Cx43 and GLP-1 in gastric emptying in patients with type 2 DGP, and the correlation of CCK, Cx43 and GLP-1 were analyzed. Results The levels of CCK and Cx43 in dyspepsia group and gastroparesis group were lower than those in control group, the levels of GLP-1 were higher than those in control group, and the gastric half-emptying time was longer than that in control group;the levels of CCK and Cx43 in gastroparesis group were lower than those in dyspepsia group, the levels of GLP-1 were higher than those in dyspepsia group, and the gastric half-emptying time was longer than that in dyspepsia group(P<0.05). The combined detection of CCK, Cx43 and GLP-1 had higher predictive value for gastric emptying in patients with type 2 DGP. CCK was positively correlated with Cx43(r=0.482;P<0.001), CCK was negatively correlated with GLP-1(r=-0.356;P<0.001), and Cx43 was negatively correlated with GLP-1(r=-0.619;P<0.001). Conclusion CCK, Cx43 and GLP-1 are abnormally expressed in type 2 DGP, which has certain value in predicting type 2 DGP.

关 键 词：糖尿病 2型 胃肌轻瘫 胃排空 预测 

分 类 号：R587.1[医药卫生—内分泌]