加味逍遥散对脑卒中后失眠症血清SP、NPY水平及生活质量的影响  

Effect of Modified Xiaoyao Powder(加味逍遥散) on Levels of SP and NPY in Serum and Quality of Life in Patients with Post-Stroke Insomnia

作　　者：于立恒[1] 李龙骧[1] 李诚诚 YU Liheng;LI Longxiang;LI Chengcheng(Fuyang People's Hospital,Fuyang 236000,Anhui,China)

机构地区：[1]阜阳市人民医院,安徽阜阳236000

出　　处：《中华中医药学刊》2022年第8期133-136,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药科学技术研究专项(2019ZX7839)。

摘　　要：目的 研究分析加味逍遥散对脑卒中后失眠症患者的血清P物质(SP)、神经肽类物质神经肽Y(NPY)水平和生活质量的影响。方法 选择2019年12月—2021年1月于医院中西医结合科就诊的脑脑卒中后失眠的122例患者作为本次研究对象,所有患者依据随机数字表法随机分为试验组和对照组,每组61例,对照组患者给予常规内科治疗艾司唑仑片,试验组给予加味逍遥散联合八段锦治疗,采用匹斯堡睡眠质量指数量表(PSQI)、疲乏量表(FS-14)、脑卒中专用生活质量评分量表(SS-QOL)评估患者治疗前后睡眠、自觉疲乏程度及患者生活质量。对比两组患者治疗前后SP和NPY,依据患者睡眠改善情况进行疗效评价。结果 治疗前,两组患者PSQI、FS-14及SS-QOL评分差异不具有统计学意义(P>0.05);经治疗后,两组患者PSQI、FS-14评分均小于治疗前,SS-QOL评分大于治疗前,试验组患者PSQI、FS-14评分小于对照组,SS-QOL评分大于对照组,差异均有统计学意义(P<0.05)。治疗前,两组患者SP、NPY差异不具有统计学意义(P>0.05)。经治疗后,两组患者SP水平均低于治疗前,NPY水平高于治疗前,试验组患者SP水平均低于对照组,NPY水平高于对照组,差异均有统计学意义(P<0.05)。两组患者经不同方法治疗后,试验组患者治疗总有效率显著高于对照组,差异有统计学意义(P<0.05)。结论 加味逍遥散治疗脑卒中后失眠症患者可以显著改善患者睡眠、疲劳和生活质量,提高治疗效果,临床效果显著,值得临床推广应用。Objective To study and analyze the effect of Modified Xiaoyao Powder(加味逍遥散) on the sleep,fatigue and quality of life in patients with post-stroke insomnia.Methods A total of 122 patients with post-stroke insomnia and status epilepticus who were treated in the Department of Traditional Chinese Medicine in the hospital from December 2019 to January 2021 were selected as the study objects.All patients were randomly divided into the experimental group and the control group according to the random number table method,61 cases in each group.The control group was given estazolam tablets,while the experimental group was given Modified Xiaoyao Powder combined with Baduanjin.The Pittsburgh Sleep Quality Index(PSQI),Fatigue Scale(FS-14) and Stroke Quality of Life Scale(SS-QOL) were used to evaluate the sleep,conscious fatigue and quality of life before and after treatment.The serum levels of substance P(SP) and neuropeptide Y(NPY) were compared between the two groups before and after treatment.Results Before treatment,the difference in PSQI,FS-14 and SS-QOL scores between the two groups was not statistically significant(P>0.05).After treatment,the PSQI and FS-14 scores of the two groups were lower than those before treatment.The QOL score was higher than that before treatment.The PSQI and FS-14 scores of the experimental group were lower than those of the control group,and the SS-QOL score was higher than that of the control group(P0.05).After treatment,the levels of SP in both groups were lower than those before treatment and the levels of NPY in both groups were higher than those before treatment,while the SP level in the experimental group was lower than that in the control group and the NPY level was higher than that in the control group,with significant differences(P<0.05).After treated by different methods,the total effective rate of the experimental group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Modified Xiaoyao Powder can si

关 键 词：脑卒中后失眠症 加味逍遥散 生活质量 睡眠改善 

分 类 号：R255.2[医药卫生—中医内科学] R256.23[医药卫生—中医学]