木香流气方结合贝那普利治疗慢性肾小球肾炎效果及安全性观察  

Effect and Safety of Muxiang Liuqi Formula(木香流气方) Combined with Benazepril in Treatment of Chronic Glomerulonephritis

作　　者：彭斌[1] 高智[1] PENG Bin;GAO Zhi(Wuhan Hospital of Traditional Chinese Medicine,Wuhan 430049,Hubei,China)

机构地区：[1]武汉市中医医院,湖北武汉430049

出　　处：《中华中医药学刊》2022年第8期217-220,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：湖北省科技计划(2017CFB485)。

摘　　要：目的 探究木香流气方结合贝那普利治疗慢性肾小球肾炎效果及安全性。方法 研究纳入117例慢性肾小球肾炎患者(2019年6月—2021年4月),采取随机数字表法将患者分成两组,对照组59例低盐低脂饮食+贝那普利治疗,观察组58例患者低盐低脂饮食+贝那普利及木香流气方治疗,比较各组患者疗效与治疗前后中医证候(腰酸、浮肿、纳差、疲乏、夜尿多等)积分变化、血压指标(收缩压及舒张压)变化、血脂指标[(甘油三酯(TG)、总胆固醇(TC)、谷丙转氨酶(GPT)]变化、血清炎症因子指标[超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、γ-干扰素(INF-γ)]水平变化、尿液中白细胞及红细胞计数情况变化、肾功能指标[血肌酐(SCr)、尿素氮(BUN)、24 h尿蛋白定量]变化、治疗不良反应。结果 与对照组患者(76.27%,45/59)对比,观察组治疗总有效率(93.10%,54/58)更高(P<0.05);两组患者治疗前中医证候(腰酸、浮肿、纳差、疲乏、夜尿多等)积分、血压指标(收缩压及舒张压)、血脂指标(TG、TC、GPT)、血清炎症因子指标(hs-CRP、IL-6、INF-γ)、尿液中白细胞及红细胞计数、肾功能指标(SCr、BUN、24 h尿蛋白定量)等指标比较,差异无统计学意义(P>0.05),治疗后两组患者中医证候(腰酸、浮肿、纳差、疲乏、夜尿多等)积分、血压指标(收缩压及舒张压)、血脂指标(TG、TC、GPT)、血清炎症因子指标(hs-CRP、IL-6、INF-γ)、尿液中白细胞及红细胞计数、肾功能指标(SCr、BUN、24 h尿蛋白定量)等指标均改善,观察组患者治疗后中医证候(腰酸、浮肿、纳差、疲乏、夜尿多等)积分、血压指标(收缩压及舒张压)、血脂指标(TG、TC、GPT)、血清炎症因子指标(hs-CRP、IL-6、INF-γ)、尿液中白细胞及红细胞计数、肾功能指标(SCr、BUN、24 h尿蛋白定量)等指标优于对照组患者(P<0.05);对照组不良反应:头痛1例,恶心2例,观察组患者头晕1例,恶心1例,两组不Objective To explore the efficacy and safety of Muxiang Liuqi Formula(木香流气方) combined with benazepril in the treatment of chronic glomerulonephritis.Methods A total of 117 patients with chronic glomerulonephritis(admitted from June 2019 to April 2021) were divided into two groups by random number table method.The control group(59 patients) were treated with low-salt and low-fat diet+benazepril.The observation group(58 patients) were treated with low-salt and low-fat diet+benazepril and Muxiang Liuqi Formula.The curative effect and TCM syndrome scores(lumbar acid,edema,anorexia,fatigue,more night urination,etc.),blood pressure indexes(systolic blood pressure and diastolic blood pressure,blood fat indexes[triglyceride(TG),total cholesterol(TC),cereal third transaminase(GPT)],serum inflammatory factor indexes[(hypersensitive C-reactive protein(hs-CRP),levels of interleukin 6(IL-6),interferon-γ(INF-γ),changes of urine white blood cell and red blood cell counts,levels of renal function indexes[serum creatinine(SCR),urea nitrogen(BUN),24 h urinary protein quantification)] and adverse reactions of two groups were compared.Results Compared with that(76.27%,45/59) of the control group,the total effective rate of the observation group(93.10%,54/58) was higher(P0.05).After treatment,TCM syndrome scores(lumbar acid,edema,anorexia,fatigue,more night urination,etc.),blood pressure indexes(systolic and diastolic blood pressures),blood lipid indexes(TG,TC,GPT),serum inflammatory factors indexes(hs-CRP,IL-6,INF-γ),urine white blood cell and red blood cell counts,renal function indexes(SCR,BUN,24 h urinary protein quantification) and other indicators in each group were improved.In the observation group after treatment,the indexes above were better than those of the control group(P0.05).Conclusion Muxiang Liuqi Formula combined with benazepril in the treatment of chronic glomerulonephritis has the advantages of less adverse reactions and good recovery of patients,which is safe and reliable and worthy of application.

关 键 词：慢性肾小球肾炎 木香流气方 贝那普利 疗效 中医证候积分 不良反应 

分 类 号：R269.923.1[医药卫生—中西医结合]