深海热液真菌Fusarium sp.SCSIO 06196中抗病毒聚酮类化学成分研究  

Antiviral chromones from the deep-sea hydrothermal-vent-derived Fusarium sp.SCSIO 06196

作　　者：王俊锋[1] 周雯颖 田新朋[1] 刘永宏[1] WANG Junfeng;ZHOU Wenying;TIAN Xinpeng;LIU Yonghong(CAS Key Laboratory of Tropical Marine Bio-resources and Ecology,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China;Fifth School of Clinical Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]中国科学院南海海洋研究所,热带海洋生物资源与生态重点实验室,广东广州510301 [2]广州中医药大学,第五临床医学院,广东广州510405

出　　处：《热带海洋学报》2022年第5期189-193,共5页Journal of Tropical Oceanography

基　　金：Science and Technology Project of Hainan Province(ZDKJ202018);National Natural Science Foundation of China(21502204,41776169)。

摘　　要：从西太平洋深海热液沉积物来源的镰刀菌SCSIO 06196中分离鉴定了6个色原酮类化合物(1~6),通过核磁共振光谱、质谱及旋光等多种分析测试方法确定了色原酮类化合物的结构。抗病毒活性筛选发现,化合物1~3展示出显著的抗肠道病毒EV-71活性,IC_(50)分别达到26.7μmol·L^(-1)、19.8μmol·L^(-1)和22.0μmol·L^(-1)(阳性对照药物利巴韦林为177μmol·L^(-1))。此外,化合物1还显示出弱的抗流感病毒H3N2活性,IC_(50)为8.6μmol·L^(-1)(阳性对照药物达菲为18.5nmol·L^(-1))。Six chromone derivatives(1~6)were identified from the fungus Fusarium sp.SCSIO 06196 isolated from deep-sea hydrothermal vent environments in the Western Pacific.Their structures were elucidated mainly by extensive Nuclear Magnetic Resonance(NMR)spectroscopic,mass spectrometric(MS)and rotational analysis.Antiviral activities of the compounds 1~6 were tested.Among these compounds,compounds 1~3 exhibited significant in vitro anti-enterovirus 71(EV-71)activities with IC_(50) values of 26.7,19.8,and 22.0μmol·L^(-1),respectively(IC_(50)=177μmol·L^(-1),Ribavirin).In addition,compound 1 showed weak antiviral activity against the H3N2 influenza virus with IC_(50) value of 8.6μmol·L^(-1)(IC_(50)=18.5 nmol·L^(-1),Tamiflu).

关 键 词：深海热液 聚酮 抗肠道病毒活性 抗流感病毒活性 

分 类 号：P735.4[天文地球—海洋生物学]