瓣膜间质细胞异质性在钙化性主动脉瓣疾病中的作用  

Regulatory role of valve interstitial cell heterogenity in calcific aortic valve disease

作　　者：钟国恒 曾庆春 ZHONG Guoheng;ZENG Qingchun(Department of Cardiology,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,China)

机构地区：[1]南方医科大学南方医院心血管内科,广东省广州市510515

出　　处：《中国动脉硬化杂志》2022年第10期829-836,共8页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金面上项目(81770386、82070403)。

摘　　要：钙化性主动脉瓣疾病(CAVD)是一种表现为主动脉瓣增厚、钙化的疾病,随病情发展可出现瓣膜硬化,进而引起一系列血流动力学的异常改变,最终可导致慢性心力衰竭和死亡。主动脉瓣膜间质细胞是构成主动脉瓣膜的主要细胞亚群,在CAVD的发生发展中起重要的作用。当前,单细胞测序等技术让研究者对间质细胞的起源、表型和功能异质性有了新的理解。文章对间质细胞的异质性在钙化性主动脉瓣疾病中所起的作用进行综述,为靶向间质细胞延缓CAVD进程提供新的思路。Calcific aortic valve disease(CAVD) is characterized by thickening and calcification of the aortic valve, which can develop into valve sclerosis, and rapidly progress to a series of abnormal hemodynamic changes, and eventually heart failure and death. Aortic valve interstitial cells, as the main cell population of aortic valve, play a key role in the development of CAVD. The development of technologies such as single cell sequencing has improved researchers’ understanding of the origin, phenotype and functional heterogeneity of interstitial cells. This article reviews the role of interstitial cell heterogeneity in calcified aortic valve disease, which may provide a new idea for targeting interstitial cells to attentuate CAVD process.

关 键 词：瓣膜间质细胞 异质性 钙化性主动脉瓣疾病 单细胞测序 

分 类 号：R542.5[医药卫生—心血管疾病]