经咽鼓管途径鼓室内灌注给药治疗突发性耳聋的效果观察  

Observation on the effect of intratympanic perfusion administration via eustachian tube in the treatment of sudden deafness

作　　者：罗平 张渊 贺丹 龚恒萃 李玲娟 LUO Ping;ZHANG Yuan;HE Dan;GONG Heng-cui;LI Ling-juan(Department of Otolaryngology,Yibin Hospital of Traditional Chinese Medicine,Yibin 644000,China)

机构地区：[1]四川省宜宾市中医医院耳鼻喉科,四川宜宾644000

出　　处：《实用医院临床杂志》2022年第5期167-170,共4页Practical Journal of Clinical Medicine

基　　金：四川省医学会科研青年创新课题(编号:Q18064)。

摘　　要：目的 探讨经咽鼓管途径鼓室内灌注给药治疗突发性耳聋患者效果。方法 纳入我院138例初治无效的突发性耳聋患者,采用随机数字表法分为对照组和研究组各69例,在挽救治疗方案中对照组采用前列地尔、腺苷钴胺和舒血宁注射液联合治疗10天,研究组在此基础上选用泼尼松龙经咽鼓管途径进行鼓室内灌注给药治疗,隔日一次,共5次。比较两组总有效率,治疗前后血液流变学和气导纯音听阈的变化以及不良反应。结果 研究组总有效率高于对照组(P<0.05)。治疗后,研究组血细胞比容、全血低切黏度、全血高切黏度和血浆黏度均低于对照组,气导纯音听阈低于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 经咽鼓管途径鼓室内灌注给药治疗突发性耳聋患者临床价值更佳,具有较好安全性。Objective To investigate the curative effect of intratympanic perfusion administration through the eustachian tube in the treatment of patients with sudden deafness.Methods One hundred and thirty-eight patients with sudden deafness who failed initial treatment in our hospital were included. The patients were divided into a control group and a study group by random number table method, 69 in each group. The control group was given the combined treatment of alprostadil, adenosylcobalamin and shuxuening injection for 10 days. On the basis of this, the study group was given prednisolone via the eustachian tube route for intratympanic perfusion therapy, once every other day and 5 times in total. The total effective rate, changes of hemorheology, air conduction pure tone hearing threshold and adverse reactions before and after treatment were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group(P<0.05). After treatment, the hematocrit, whole blood low shear viscosity, whole blood high shear viscosity and plasma viscosity in the study group were lower than those in the control group(P<0.05). The air conduction pure tone hearing threshold in the study group was lower than that in the control group(P<0.05). There was no statistical significance in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The intratympanic perfusion administration through the eustachian tube has better clinical value and better safety in the treatment of patients with sudden deafness.

关 键 词：突发性耳聋 咽鼓管 鼓室内灌注给药 泼尼松龙 挽救治疗 安全性 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]