MHR对原发性高血压患者左室肥厚的预测价值  

Predictive value of monocyte and high-density lipoprotein cholesterol ratio for left ventricular hypertrophy in patients with essential hypertension

作　　者：李秀珍[1] 曲晨[2] 郭守玉[1] LI Xiuzhen;QU Chen;GUO Shouyu(Department of Cardiology,Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210011,China;Department of Geriatrics,Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210011,China)

机构地区：[1]南京医科大学第二附属医院心血管内科,江苏南京210011 [2]南京医科大学第二附属医院老年医学科,江苏南京210011

出　　处：《检验医学与临床》2022年第19期2593-2595,2600,共4页Laboratory Medicine and Clinic

基　　金：国家自然科学基金项目(81971317)。

摘　　要：目的探讨单核细胞与高密度脂蛋白胆固醇比值(MHR)对原发性高血压(EHT)患者左室肥厚的预测价值。方法选取2018年3月至2019年9月于南京医科大学第二附属医院心血管内科初诊为EHT的患者101例为EHT组,同时期74例健康体检者作为对照组。收集两组一般临床信息,检测血常规、血生化,检查心脏彩超。结果EHT组的体质量指数(BMI)、三酰甘油(TG)、MHR均高于对照组(P<0.05);预估肾小球滤过率(eGFR)低于对照组(P<0.05)。BMI、MHR增高是EHT发生的独立危险因素(P<0.05),随着BMI、MHR的增高,EHT发生的风险显著增加。受试者工作特征曲线(ROC曲线)提示,MHR的cut-off值为4.45时,对EHT发生的预测价值最高(灵敏度为74.3%,特异度为55.4%,曲线下面积为0.652,95%CI:0.569~0.736,P=0.001)。根据MHR的cut-off值4.45,将所有受试者分为MHR≥4.45组以及MHR<4.45组,MHR≥4.45组的左室质量指数(LVMI)大于MHR<4.45组(P<0.05)。LVMI与MHR呈正相关(r=0.178,P=0.038)。结论MHR在EHT患者中升高,与LVMI呈正相关,可以作为左室肥厚的预测因子。Objective To explore the predictive value of monocyte and high-density lipoprotein cholesterol ratio(MHR)for left ventricular hypertrophy in patients with essential hypertension(EHT).Methods A total of 101 patients who were newly diagnosed with EHT from March 2018 to September 2019 in the Department of Cardiology of the Second Affiliated Hospital of Nanjing Medical University were enrolled,and 74 healthy people during the same period were used as the control group.People general clinical information were collected,blood routine,blood biochemistry,and heart color Doppler ultrasound were detected.Results Body mass index(BMI),triacylglycerol(TG),and MHR in the EHT group were higher than those in the control group(P<0.05),estimated glomerular filtration rate(eGFR)was lower than that of the control group(P<0.05).BMI and MHR increased were independent risk factors for the occurrence of EHT(P<0.05),the risk of EHT increased with higher BMI or MHR.Receiver operating characteristic(ROC)curve indicated that when the MHR cut-off value was 4.45,the diagnostic predictive value of EHT patients was the highest(sensitivity was 74.3%,specificity was 55.4%and area under the curve was 0.652,95%CI:0.569-0.736,P=0.001).According to the cut-off value of MHR was 4.45,all subjects were divided into two groups:MHR≥4.45 group and MHR<4.45 group.Left ventricular mass index(LVMI)in the MHR≥4.45 group was greater than that in the MHR<4.45 group(P<0.05).The LVMI and MHR of subjects were positively correlated(r=0.178,P=0.038).Conclusion MHR increases in EHT patients,and is positively correlated with LVMI,which can be used as a predictor of left ventricular hypertrophy.

关 键 词：单核细胞与高密度脂蛋白胆固醇比值 原发性高血压 左室肥厚 左室质量指数 

分 类 号：R543.1[医药卫生—心血管疾病]