血清NDRG4、sB7-H4对上皮性卵巢癌患者肿瘤细胞减灭术后复发的预测价值  

Predictive value of serum NDRG4 and sB7-H4 for recurrence after primary tumor cell reduction in patients with epithelial ovarian cancer

作　　者：裴益明 王蕾 王苗 PEI Yiming;WANG Lei;WANG Miao(Department of Clinical Laboratory,Xianyang First People′s Hospital,Xianyang,Shaanxi 712000,China;Department of Obstetrics and Gynecology,Xianyang First People′s Hospital,Xianyang,Shaanxi 712000,China)

机构地区：[1]咸阳市第一人民医院检验科,陕西咸阳712000 [2]咸阳市第一人民医院妇产科,陕西咸阳712000

出　　处：《检验医学与临床》2022年第19期2643-2646,2650,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨血清抑癌基因N-myc下游调节因子4(NDRG4)、可溶性B7-H4(sB7-H4)对上皮性卵巢癌(EOC)患者肿瘤细胞减灭术(PTCR)后复发的预测价值。方法选择2015年6月至2018年6月在咸阳市第一人民医院妇产科行PTCR的85例EOC患者为研究对象,术前检测血清NDRG4、sB7-H4水平,术后均给予常规化疗,出院后均定期随访3年,统计复发例数,根据复发情况将患者分为复发组和未复发组。分析EOC患者PTCR后复发的影响因素以及血清NDRG4、sB7-H4预测EOC患者PTCR后复发的价值。结果随访3年,失访2例,剩余83例患者中复发32例,未复发51例,复发率为38.55%。复发组术前血清NDRG4水平低于未复发组(P<0.05),sB7-H4水平高于未复发组(P<0.05)。多因素Logistic回归分析结果显示,残余病灶最大径≥1 cm、NDRG4水平降低、sB7-H4水平升高是EOC患者PTCR后复发的危险因素(P<0.05)。联合NDRG4、sB7-H4预测EOC患者PTCR后复发的曲线下面积为0.806,高于两指标单独检测的0.706、0.711。结论血清NDRG4水平降低、sB7-H4水平升高、残余病灶最大径≥1 cm是EOC患者PTCR后复发的危险因素,联合检测NDRG4、sB7-H4对于术后复发风险具有一定预测价值。Objective To investigate the predictive value of serum tumor suppressor gene N-myc downstream regulator 4(NDRG4)and soluble B7-H4(sB7-H4)for recurrence after primary tumor cell reduction(PTCR)in patients with epithelial ovarian cancer(EOC).Methods A total of 85 patients with EOC who underwent PTCR in Xianyang First People′s Hospital from June 2015 to June 2018 were selected.Serum NDRG4 and sB7-H4 levels were detected before surgery,and routine chemotherapy was given after surgery.All patients were followed up for 3 years after discharge.The number of recurrence cases were counted,and patients were divided into recurrence group and non-recurrence group according to the recurrence situation.Influencing factors of recurrence PTCR in patients with EOC were analyzed,and the value of serum NDRG4 and sB7-H4 in predicting recurrence after after PTCR in patients with EOC.Results In the follow-up of 3 years,two cases were lost to follow-up,32 cases recurred,51 cases did not relapse,and the recurrence rate was 38.55%.The preoperative serum NDRG4 level in the recurrence group was lower than that in the non-recurrence group(P<0.05).The sB7-H4 level was higher than that in the non-recurrence group(P<0.05).Multivariate Logistic regression showed that residual lesion≥1 cm,reduced NDRG4 level,and increased sB7-H4 level were risk factors for recurrence after PTCR in patients with EOC(P<0.05).Combined with NDRG4 and sB7-H4,the area under the curve for predicting the recurrence after PTCR in patients with EOC was 0.806,which was higher than 0.706 and 0.711 detected by the two indexes alone.Conclusion The decrease of serum NDRG4 level,the increase of sB7-H4 level and residual lesion≥1 cm are the risk factors of recurrence after PTCR in patients with EOC.The combined detection of NDRG4 and sB7-H4 has a certain predictive value for the risk of postoperative recurrence.

关 键 词：N-myc下游调节因子4 可溶性B7-H4 上皮性卵巢癌 肿瘤细胞减灭术 复发 预测价值 

分 类 号：R446.1[医药卫生—诊断学]