开玄泄浊方治疗寻常型银屑病(阳虚外寒证)临床观察  

Clinical Observation on Kaixuan Xiezhuo Prescription in the Treatment of Psoriasis Vulgaris(Yang Deficiency and External Cold Syndrome)

作　　者：赵云 刘朝圣[2] 钟昕 谭素芳 周琦 ZHAO Yun;LIU Chaosheng;ZHONG Xin;TAN Sufang;ZHOU Qi(Department of Dermatology,Xiangtan County Hospial,Hunan Province,Xiangan 411228,China;Department of Dermatology,the First Affiliated Hospital of Hunan University of Chinese Medicine,Hunan Province,Changsha 410007,China;Grade 2019 Graduate,Hunan University of Chinese Medicine,Hunan Province,Changsha 410208,China)

机构地区：[1]湘潭县人民医院皮肤科,湖南湘潭411228 [2]湖南中医药大学第一附属医院皮肤科,湖南长沙410007 [3]湖南中医药大学,湖南长沙410208

出　　处：《光明中医》2022年第18期3333-3336,共4页GUANGMING JOURNAL OF CHINESE MEDICINE

基　　金：湖南省卫生健康委科学研究课题(No.20201181);湖南中医药大学中西医结合一流学科开放基金重点项目(No.2020ZXYJH06)。

摘　　要：目的 观察“开玄泄浊方”治疗寻常型银屑病阳虚外寒证的临床疗效。方法 选取符合寻常型银屑病阳虚外寒证患者60例,随机等分为治疗组和对照组各30例;治疗组采取自拟开玄泄浊方,对照组采用雷公藤多苷片口服,2组均外用达力士软膏,连续用药8周;分别于治疗前、治疗4周、治疗8周记录2组患者皮损面积、红斑、鳞屑、浸润评分、银屑病面积与严重性指数(PASI)积分、瘙痒程度评分及出现的不良反应,运用统计学工具,比较2组疗效差异。结果 治疗8周后,2组PASI积分、瘙痒程度评分均较治疗前差异有统计学意义(P <0.05),且治疗组明显优于对照组;治疗组总有效率明显高于对照组,2组差异具有统计学意义(P <0.01)。结论 基于玄府理论的自拟“开玄泄浊方”治疗寻常型银屑病阳虚外寒证临床疗效显著,可为临床寻常型银屑病中医辨证论治提供参考。Objective To observe the clinical efficacy of Kaixuan Xiezhuo prescription in the treatment of psoriasis vulgaris(yang deficiency and external cold syndrome),and to provide evidence-based evidence for the treatment of psoriasis vulgaris by open Kaixuan Xiezhuo prescription. Methods Sixty psoriasis vulgaris patients with yang deficiency and external cold syndrome were randomly divided into treatment group and control group,with 30 cases in each group. The treatment group was treated with Kaixuan Xiezhuo prescription and the control group was treated with Tripterygium wilfordii polyglycoside tablets,and the patients in both groups were treated with Daivonex for basic treatment of Psoriasis for 8 weeks. Before treatment,after 4 weeks and 8 weeks of continuous treatment,the lesion area,erythema,scale,infiltration score,(PASI) score of Psoriasis Area and Severity Index,pruritus score and adverse reactions during treatment were recorded in the two groups. Statistical software was used to compare the curative effect between the two groups. Results After two courses of treatment(8 weeks),the scores of PASI and pruritus in the treatment group and the control group were significantly different from those before the treatment(P < 0. 05),and the treatment group was significantly better than the control group. The total effective rate in the treatment group was significantly higher than that in the control group,and the treatment group was significantly better than the control group(P < 0. 01). Conclusion The self-made Kaixuan Xiezhuo prescription which based on Xuanfu theory is effective in the treatment of psoriasis vulgaris with yang deficiency and external cold syndrome. It can provide reference for traditional Chinese medicine syndrome differentiation and treatment of psoriasis vulgaris.

关 键 词：白疕 玄府理论 开玄泄浊法 银屑病 阳虚外寒证 中医药疗法 

分 类 号：R275.9[医药卫生—中西医结合]