健脾补肾止泻方结合西医常规疗法治疗糖尿病性腹泻脾肾阳虚证临床研究  

The clinical study of Jianpi Bushen Zhixie Recipe combined with conventional western medicine therapy for the patients wit diabetic diarrhea and spleen and kidney yang-deficiency syndrome

作　　者：马葳 田浩君 孙秀清 孙启胜 李鹏[5] Ma Wei;Tian Haojun;Sun Xiuqing;Sun Qisheng;Li Peng(Department of Geriatrics,Shunyi Hospital,Beijing Traditional Chinese Medicine Hospital,Beijing 101300,China;Department of Traditional Chinese Medicine,Jinfang National Medical Hospital,Beijing 101318,China;Jingshun Traditional Chinese Medicine Hall,Beijing Jingshun Hospital,Beijing 101300,China;School of Acupuncture and Massage,Beijing University of Chinese Medicine,Beijing 100029,China;Medical Experimental Center,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]北京中医医院顺义医院老年病科,北京101300 [2]北京杏园金方国医医院中医内科,北京101318 [3]北京京顺医院京顺中医堂,北京101300 [4]北京中医药大学针灸推拿学院,北京100029 [5]中国中医科学院医学实验中心,北京100700

出　　处：《国际中医中药杂志》2022年第9期992-995,共4页International Journal of Traditional Chinese Medicine

基　　金：北京市顺义区首批名老中医药专家学术经验继承工作项目(〔2017〕19号)。

摘　　要：目的评价健脾补肾止泻方结合西医常规疗法治疗糖尿病性腹泻脾肾阳虚证临床疗效。方法将符合入选标准的2019年6月-2021年6月北京中医医院顺义医院62例糖尿病性腹泻患者按随机数字表法分为2组,每组31例。对照组采用西医常规疗法治疗,治疗组在对照组基础上服用健脾补肾止泻方。2组均连续治疗2周,随访2周。分别于治疗前后进行中医证候评分及Bristol大便性状分型量表(BSFS)评分,采用健康状况相关生活质量量表(SF-36)评价患者生活质量,记录治疗前后排便次数、治疗期间的不良反应及随访期间的复发率。结果治疗组总有效率为93.55%(29/31)、对照组为74.19%(23/31),2组比较差异有统计学意义(χ^(2)=5.44,P=0.020)。治疗后,治疗组排便次数[(1.02±0.23)次/d比(2.35±0.45)次/d,t=14.65]低于对照组(P<0.01);BSFS评分、中医证候评分均低于对照组(t值分别为11.87、12.96,P值均<0.001);SF-36评分高于对照组(t=7.85,P<0.01)。2组治疗期间均未发生不良反应。随访期间,对照组复发4例(4/23),治疗组无复发患者,2组比较差异有统计学意义(χ^(2)=4.28,P=0.039)。结论健脾补肾止泻方结合西医常规疗法可有效改善糖尿病性腹泻患者的临床症状,降低不良反应,减少复发率,提高临床疗效。Objective To evaluate the clinical efficacy of Jianpi Bushen Zhixie Recipe combined with conventional western medicine therapy in the treatment of diabetic diarrhea patients with spleen and kidney yang-deficiency syndrome.Methods According to the random number table method,62 patients with diabetic diarrhea with spleen and kidney yang-deficiency syndrome from June 2019 to June 2021 in Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital,who met the inclusion criteria,were divided into two groups,with 31 in each group.The control group was treated with standardized hypoglycemic and mecobalamin treatment,while the treatment group was treated with Jianpi Bushen Zhixie Recipe on the basis of the control group.Both groups were treated for 2 weeks and followed up for 2 weeks.Before and after treatment,TCM syndrome scores and Bristol Stool Form Scale(BSFS)scores were performed before and after treatment.The Health Related Quality of Life Scale(SF-36)was used to evaluate the quality of life of patients.The number of bowel movements and adverse reactions during treatment were recorded before and after treatment,and followed up for 2 weeks to observe the disease recurrence rate.Results The total effective rate was 93.55%(29/31)in the treatment group and 74.19%(23/31)in the control group,with a statistically significant difference between both groups(χ^(2)=5.44,P=0.020).After treatment,the number of bowel movements in the treatment group[(1.02±0.23)times/d vs.(2.35±0.45)times/d,t=14.65]was significantly lower than that of the control group(P<0.01);the BSFS scores(1.93±0.43 vs.3.23±0.43,t=11.87)and TCM syndrome score(0.93±0.25 vs.1.95±0.36,t=12.96)in the treatment group were significantly lower than those in the control group(P<0.01);the SF-36 score(92.32±2.99 vs.86.23±3.12,t=7.85)in the treatment group was significantly higher than that of the control group(P<0.01).No gastrointestinal adverse events were found in both groups during treatment.During the follow-up period,there were 4 cases(4/23)of recurre

关 键 词：糖尿病 腹泻 糖尿病并发症 健脾补肾止泻方 中西医结合疗法 

分 类 号：R587.2[医药卫生—内分泌]