Effect of 0.01%atropine eyedrops on intraocular pressure in schoolchildren:a randomized clinical trial  

作　　者：Javaria Bukhari Shi-Fei Wei Shi-Ming Li Wen-Zai An Jia-Ling Du Xin-Tong Liang Jia-He Gan Jia-Xin Tian Wei-Ling Bai Zhi-Ning Cai Lei Yin Ning-Li Wang 

机构地区：[1]Beijing Institute of Ophthalmology,Beijing Tongren EyeCenter,Beijing Tongren Hospital,Capital Medical University,Bejing Ophthalmology&Visual Sciences Key Laboratory,Beijing 100730,China [2]Capital Medical University,Bejing 100069,China [3]Department of Ophthalmology,Zhengzhou First People's Hospital,Zhengzhou 45004,Henan Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2022年第9期1431-1436,共6页国际眼科杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.82071000);the Beijing Science Foundation for Distinguished Yong Scholars(No.JQ20029);the Capital Health Research and Development of Special(No.2020-2-1081);Supported by the Beijing Municipal Administration of Hospitals Incubating Program(No.PX2022007);the Primary Scientific Research Foundation for the Junior Researcher in Beijing Tongren Hospital,Capital Medical University(No.2020-YJJ-ZZL-011)。

摘　　要：·AIM:To assess the effect of 0.01%atropine eye drops on intraocular pressure(IOP)in myopic children.·METHODS:A placebo-controlled,double-masked,randomized study.Totally 220 children aged 6 to 12 y with myopia ranging from-1.00 to-6.00 D in both eyes were enrolled.Children were randomized in a 1:1 ratio to either 0.01%atropine eye drops or a placebo group using generated random numbers.All participants underwent the examination of IOP and cycloplegic refraction at baseline,6 and 12 mo.The change of IOP and the proportion of subjects with increased IOP in atropine and placebo groups were compared.·RESULTS:Of 220 children,117 were boys(53.2%).A total of 159(72.3%)participants completed the follow-up at the 1-year study.At baseline,the mean IOP was 15.74 mm Hg(95%CI,15.13 to 16.34 mm Hg)for the 0.01%atropine group and 15.59 mm Hg(95%CI,15.00 to 16.19 mm Hg)for placebo group(mean difference,0.14 mm Hg;P=0.743)after adjusting for central corneal thickness at baseline.At one year follow-up,the mean change of IOP was 0.16 mm Hg(95%CI,-0.43 to 0.76 mm Hg)for the 0.01%atropine group and-0.11 mm Hg(95%CI,-0.71 to 0.50 mm Hg)for placebo group(mean difference,0.27 mm Hg;P=0.525)after adjusting for central corneal thickness.The 51.4%of children have increased IOP in the 0.01%atropine group,compared with 45.9%in the placebo group(P=0.511).·CONCLUSION:The 0.01%atropine eye drops do not significantly affect the risk of elevated IOP.It is relatively safer to use in the studies that try to minimize myopia progression.However,a further long-duration study is required to be validated.

关 键 词：intraocular pressure 0.01%atropine eye drops myopic children 

分 类 号：R969[医药卫生—药理学]