子宫内膜损伤的病因与发病机制  

Etiology and pathogenesis of endometrial injury.

作　　者：蔡慧华 何援利[2] CAI Hui-hua;HE Yuan-li(Department of Obstet-rics and Gynecology,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China;Department of Obstet-rics and Gynecology,Zhujiang Hospital,Southern Medical University,Guangzhou 510280,China)

机构地区：[1]广东省人民医院(广东省医学科学院)妇产科,广东广州510080 [2]南方医科大学珠江医院妇产科,广东广州510280

出　　处：《中国实用妇科与产科杂志》2022年第9期869-873,共5页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：国家自然科学基金(81701396,81270658)。

摘　　要：创伤和感染是子宫内膜损伤的重要病因,子宫内膜损伤严重、深达子宫内膜基底层可引起子宫内膜修复障碍,表现为宫腔部分或全部闭塞的宫腔粘连(intrauterine adhesions,IUA),导致月经量减少、闭经、复发性流产和不孕等。IUA分离术后易复发、高复发已成为临床瓶颈,因此针对其病因机制的防治问题亟待解决。文章阐述了子宫内膜损伤尤其是IUA的病因及发病机制的研究进展。Trauma and infection are important factors of endometrial injury.Severe endometrial injury as deep as the basal layer of endometrium can cause endome⁃trial repair disorder,which is manifested as intrauterine adhesions(IUA)with partial or total occlusion.IUA often leads to hypomenorrhea,amenorrhea and infer⁃tility.The frequent and high recurrence of IUA after separation has become a clinical bottleneck.Thus,the prevention and treatment of its etiological mechanism urgently need to be solved.In this paper,the etiology and pathogenesis of endometrial injury,especially IUA,are reviewed.

关 键 词：子宫内膜损伤 宫腔粘连 病因 发病机制 研究进展 

分 类 号：R711.7[医药卫生—妇产科学]