不同方法对子宫内膜损伤修复的治疗结局探讨  

Treatment outcome of different methods for en⁃dometrial injury repair.

作　　者：王素敏[1] 花向东[1] WANG Su-min;HUA Xiang-dong(Department of Gynecology,Women's Hospital of Nanjing Medical University,Nanjing Maternity and Child Health Care Hospital,Nanjing 210004,China)

机构地区：[1]南京医科大学附属妇产医院妇科,江苏南京210004

出　　处：《中国实用妇科与产科杂志》2022年第9期885-891,共7页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：国家自然科学基金(81701399)。

摘　　要：宫腔粘连术后目前临床常用雌激素等药物来促进子宫内膜生长、改善子宫血流;用羊膜、透明质酸等生物屏障或材料、宫内节育器或球囊等物理屏障来预防再粘连,一定程度上减少了粘连复发,改善了生殖预后,但对重度宫腔粘连的治疗效果有限;一些促进子宫内膜损伤修复的新型治疗方法如干细胞、外泌体结合生物材料、组织工程和物理治疗等尚在研究阶段,其常规应用于临床尚需深入研究以明确其效果和安全性。Estrogen and other drugs are commonly used to promote endometrial growth and improve uterine blood flow after intrauterine adhesion surgery.Biolog⁃ical barriers or materials such as amniotic membrane and hyaluronic acid,as well as physical barriers such as intrauterine device and balloon are used to reduce the recurrence of adhesion and improve the repro⁃ductive outcomes,but the therapeutic effect on severe intrauterine adhesion is still limited.Some new treat⁃ment strategies such as stem cells,exosomes combined with biomaterials,tissue engineering and physiotherapy to promote the repair of endometrial injury are still in the research stage.Their clinical application needs further research to clarify the effect and safety.

关 键 词：宫腔粘连 损伤修复 雌激素 干细胞 

分 类 号：R711.4[医药卫生—妇产科学]