基于影像的计算流体力学在主动脉缩窄评估中的研究进展  

Research advances in assessing aortic coarctation by image-based computational fluid dynamics

作　　者：秦津洁 何玲[1,2] Qin Jinjie;He Ling(Department of Radiology,Affiliated Children's Hospital,Chongqing Medical University,Chongqing 400014,China;Ministry of Education Key Laboratory of Child Development&Disorders,National Clinical Research Center for Child Health&Disorders,China International Science&Technology Cooperation Base of Child Development&Critical Disorders,Chongqing Key Laboratory of Pediatrics,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院放射科,重庆400014 [2]儿童发育疾病研究教育部重点实验室,国家儿童健康与疾病临床医学研究中心,儿童发育重大疾病国家国际科技合作基地,儿科学重庆市重点实验室,重庆400014

出　　处：《临床小儿外科杂志》2022年第8期780-784,共5页Journal of Clinical Pediatric Surgery

基　　金：重庆市科卫联合医学科研项目(2020FYYX128);重庆市技术创新与应用发展专项重点项目(CSTC2021jscx-gksb-N0018)。

摘　　要：主动脉缩窄是指胸主动脉降段一定程度狭窄,是儿童较常见的先天性心脏病。现有多种诊断标准均基于计算影像学上主动脉不同层面直径之间的比例关系评估主动脉缩窄,不能充分反映主动脉血流动力学状态,不利于制定最佳的个体化手术方案。心导管测压虽然可以充分反映主动脉整体血流动力变化,但是一种侵入性检查,不作为临床首选,因此临床亟需一种无创方式可视化评估患儿复杂的血流动力学变化。近年来,基于影像学资料的计算流体力学通过医工结合的方法计算血管的血流动力学指标,在成人血管性疾病中已崭露头角,有望为主动脉缩窄的诊断及治疗提供一种准确且无创的评价方法。本文将阐述基于影像的计算流体力学在主动脉缩窄无创评估中的研究进展。Aortic coarctation(CoA)refers to a narrowing of descending thoracic aorta.Various existing diagnostic parameters have indicated that single geometric phenomena such as morphological diameter or proportion fails to reflect the full view of aorta and formulate an optimal surgical plan.Although cardiac catheterization may reflect the overall hemodynamic changes of aorta,such an invasive mode is not a first clinical choice.A non-invasive mode of visually evaluating complex hemodynamic changes is urgently needed.In recent years,computational fluid dynamics(CFD)has been widely applied in vascular diseases for its highly accurate and non-invasive hemodynamic evaluation based upon medical and engineering integration.Thus it is suitable for the severity assessment and treatment guidance of CoA.Here the latest researches of CFD in CoA was summarized along with other imaging studies in CoA.

关 键 词：主动脉缩窄 计算流体力学 壁剪切应力 人工智能 

分 类 号：R725.4[医药卫生—儿科]