Calciphylaxis是误称,“钙化防御”是误译  

Calciphylaxis is a misnomer and the Chinese translation of calciphylaxis is also a wrong name

作　　者：曹仰铭 Yang-ming Cao(Divisions of Nephrology,Department of Internal Medicine,UCSF Fresno Center for Medical Education and Research,155 N Fresno St,Fresno,CA 93701,USA;The Nephrology Group,Inc,568 E Herndon Ave,Suite 201,Fresno,CA 93720,USA)

机构地区：[1]美国加州弗雷斯诺市,加州大学旧金山分校弗雷斯诺医学教育和研究中心内科肾病专科93720加利福尼亚,加利福尼亚93701 [2]美国加州弗雷斯诺市肾病组(集团)

出　　处：《中国血液净化》2022年第9期628-632,共5页Chinese Journal of Blood Purification

摘　　要：本综述解释了calciphylaxis一词起源于1961年皮肌炎的动物实验模型,后来被借用过来以解释肾病患者的钙化现象。由于两者发病机制和病理的不同,显然把calciphylaxis用在肾病患者就是误称(misnomer)。于是就引入了钙化性尿毒症性细动脉病(calcific uremic arteriolopathy,CUA)以描述肾病患者的这一综合征。但是它也可以发生于肾功能正常的人,故CUA也不大妥。所以,最近我们提出钙化性细动脉病(calcific arteriolopathy)一词,以更准确地描述这一临床综合征。同时介绍实际工作中诊断calciphylaxis的体会。还简要提及一个在许多国家不大提到的Martorell HYTILU这一诊断,及其与calciphylaxis的关系。重点指出,calciphylaxis是由calcium(钙)和anaphylaxis(严重过敏反应)这两个词组合而来。而“钙化防御”(“calcification defense”)显然是来源于calcium(钙)和prophylaxis(预防)的组合。也就是既往的译者把calciphylaxis所含的anaphylaxis误解为prophylaxis。因此,把calciphylaxis改成calcific arteriolopathy并译成钙化性细动脉病,可能是更好的选择。This review article explains that the term calciphylaxis originated from an animal model studying dermatomyositis in 1961.Shortly,it was borrowed to explain the calcification syndrome found in chronic kidney disease patients.But calciphylaxis in animal model and the calcification syndrome in kidney patients have different pathogenesis and different pathological findings.Obviously calciphylaxis is a misnomer for kidney patients.Therefore,calcific uremic arteriolopathy(CUA)was proposed to explain the calcification syndrome in kidney patients.However,this syndrome can also occur in patients without kidney failure,including patients with normal kidney function,which will make CUA not suitable for such patients.Therefore,recently we proposed the term“calcific arteriolopathy”to more accurately describe this calcification syndrome in patients with normal kidney function as well as those with kidney diseases.We also shared our experience in diagnosing CUA.For comparison,Martorell HYTILU(hypertensive ischemic leg ulcer),a diagnosis not commonly made in many countries,is reviewed.Apparently HYTILU and calciphylaxis are the same entity.In addition,we also points out that the term calciphylaxis is the combination of calcium and anaphylaxis,while“钙化防御”(“calcification defense”)is obviously from the combination of calcium and prophylaxis.In other words,the previous translator mistook anaphylaxis for prophylaxis.Therefore calcific arteriolopathy is a better term to describe the syndrome and is easier to be translated into Chinese.

关 键 词：CALCIPHYLAXIS 误称 钙化防御 错误翻译 钙化性细动脉病 

分 类 号：R692[医药卫生—泌尿科学]