不同病程自身免疫性卵巢早衰患者血清BMP15、IL-1β、INHB、MIF的变化及与性激素和T淋巴细胞亚群的相关性研究  

Changes of Serum BMP15,IL-1β,INHB and MIF in Patients with Different Stages of Autoimmune Premature Ovarian Failure and Their Correlation Study with Sex Hormones and Peripheral Blood T Lymphocyte Subsets

作　　者：王龙影 许文强 顾丽霞 赵雅璇 曹君阳 WANG Long-ying;XU Wen-qiang;GU Li-xia;ZHAO Ya-xuan;CAO Jun-yang(Department of Obstetrics and Gynecology,The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,075000,China)

机构地区：[1]河北北方学院附属第一医院妇产科,河北张家口075000

出　　处：《现代生物医学进展》2022年第18期3568-3572,共5页Progress in Modern Biomedicine

基　　金：河北省医学科学研究重点课题计划项目(201800836)。

摘　　要：目的:分析不同病程的自身免疫性卵巢早衰(APOF)患者血清骨形态发生蛋白15(BMP15)、白介素-1β(IL-1β)、血清抑制素B(INHB)、巨噬细胞移动抑制因子(MIF)变化及其与血清性激素、外周血T淋巴细胞亚群相关指标表达的关系。方法:选取2021年1月至12月期间在河北北方学院附属第一医院就诊且被确诊为APOF的52例患者纳入APOF组,另选取同期在河北北方学院附属第一医院体检且确定为卵巢功能正常的健康女性50例纳入健康组,比较APOF组与健康组、不同病程的APOF患者血清BMP15、IL-1β、INHB、MIF水平差异,比较APOF组与健康组血清性激素水平和外周血T淋巴细胞亚群水平差异,分析血清BMP15、IL-1β、INHB、MIF与血清性激素水平和外周血T淋巴细胞亚群水平的相关性。结果:APOF组血清BMP15、INHB水平较健康组明显降低,APOF组血清IL-1β、MIF水平较健康组均明显升高(均P<0.05);病程>3年的患者血清BMP15、INHB水平较病程≤3年的患者明显降低,血清IL-1β、MIF水平明显升高(均P<0.05);APOF组促卵泡激素(FSH)较健康组明显升高,血清雌二醇(E_(2))水平较健康组明显降低(均P<0.05);APOF组CD4^(+)水平较健康组明显降低(P<0.05);血清BMP15、INHB与FSH及CD4^(+)呈明显负相关,与E_(2)呈明显正相关,血清IL-1β、MIF与FSH及CD4^(+)呈明显正相关,与E_(2)呈明显负相关(均P<0.05)。结论:APOF患者随着病程延长,其血清BMP15、INHB水平呈下降趋势,血清IL-1β、MIF水平呈上升趋势,且上述各指标与患者性激素水平及外周血T淋巴细胞亚群水平密切相关。Objective:To analyze the changes of serum bone morphogenetic protein-15(BMP15),interleukin-1β(IL-1β),serum inhibin B(INHB)and macrophage migration inhibitory factor(MIF)in patients with autoimmune premature ovarian failure(APOF)and their relationship with the expression of serum sex hormones and peripheral blood T lymphocyte subsets.Methods:52 patients diagnosed with APOF who visited The First Affiliated Hospital of Hebei North University from January to December 2021 were included in the APOF group,and 50 healthy women with normal ovarian function who underwent physical examination in The First Affiliated Hospital of Hebei North University during the same period were included in the health group.The levels differences of serum BMP15,IL-1β,INHB and MIF between APOF group and healthy group,patients with different stages of APOF were compared,and the levels differences of serum sex hormones and peripheral blood T lymphocyte subsets were compared between APOF group and healthy group.The correlation of serum BMP15,IL-1β,INHB,MIF with serum sex hormone levels and peripheral blood T lymphocyte subsets was analyzed.Results:The levels of serum BMP15 and INHB in APOF group were significantly lower than those in healthy group,while the levels of serum IL-1βand MIF in APOF group were significantly higher than those in healthy group(all P<0.05).The levels of serum BMP15 and INHB in patients with course of disease>3 years were significantly lower than those in patients with course of disease≤3 years,while the levels of serum IL-1βand MIF were significantly increased(all P<0.05).Follicle stimulating hormone(FSH)in APOF group was significantly higher than that in healthy group,the level of serum estradiol(E_(2))was significantly lower than that in healthy group(all P<0.05).The level of CD4^(+)in APOF group was significantly lower than that in healthy group(P<0.05).Serum BMP15 and INHB were negatively correlated with FSH and CD4^(+),and positively correlated with E_(2),serum IL-1βand MIF were positively correlated with

关 键 词：自身免疫性卵巢早衰 BMP15 IL-1Β INHB MIF 性激素 T淋巴细胞亚群 相关性 

分 类 号：R711.75[医药卫生—妇产科学]