猪繁殖与呼吸综合征病毒NSP4研究进展  

Progress on NSP4 Gene of Porcine Reproductive and Respiratory Syndrome Virus

作　　者：沙惠阳 张航 黄良宗 马春全 赵孟孟 SHA Hui-yang;ZHANG Hang;HUANG Liang-zong;MA Chun-quan;ZHAO Meng-meng(College of Life Science and Engineering,Foshan University,Foshan Guangdong,528231,China)

机构地区：[1]佛山科学技术学院生命科学与工程学院,广东佛山528231

出　　处：《动物医学进展》2022年第10期80-85,共6页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(31902279)。

摘　　要：猪繁殖与呼吸综合征(PRRS)是由猪繁殖与呼吸综合征病毒(PRRSV)感染引起的一种高度接触性传染病。PRRSV编码NSP4具有3C样丝氨酸蛋白酶(3C-like serine proteinase,3CLSP)活性,以保守氨基酸His39-Asp64-Ser118为催化三联体,将pp1a和pp1ab水解成多个非结构蛋白(NSP3~NSP12)。NSP4在调控PRRSV复制、抑制干扰素(interferon,IFN)、早期感染诊断以及诱导细胞凋亡等方面具有重要作用。对NSP4进行综述,为防控PRRS及开发新疫苗提供理论基础。Porcine reproductive and respiratory syndrome(PRRS)is a viral infectious disease caused by porcine reproductive and respiratory syndrome virus(PRRSV).NSP4 encoded by PRRSV has 3C like serine protease activity.It uses the conserved amino acid sequence his39-asp64-ser118 as the catalytic triplet to hydrolyze pp1a and pp1ab into multiple nonstructural proteins(NSP3-NSP12).NSP4 plays an important role in PRRSV replication,inhibition of interferon production and induction of apoptosis.NSP4 protein and its antibody can be used as an important indicator of whether the body is infected with virus or not,and can be used for early diagnosis of infection.In this paper,the NSP4 gene of PRRSV was reviewed to provide help for further prevention and treatment of PRRSV and development of new vaccines.

关 键 词：猪繁殖与呼吸综合征病毒 NSP4 先天免疫 

分 类 号：S852.651[农业科学—基础兽医学] S858.28[农业科学—兽医学]