聚多巴胺基纳米材料的结构和抗氧化性能调控及其应用研究进展  

Research Progress on the Regulation of Structure and Antioxidant Properties of Polydopamine-Based Nanomaterials and Their Biomedical Applications

作　　者：叶自强 毛峥伟[1,2] YE Ziqiang;MAO Zhengwei(Key Laboratory of Polymer Synthesis and Functional Structure,Ministry of Education,Hangzhou 310027,China;Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China)

机构地区：[1]教育部高分子合成与功能构造重点实验室,浙江杭州310027 [2]浙江大学高分子科学与工程系,浙江杭州310027

出　　处：《中国材料进展》2022年第9期679-688,共10页Materials China

基　　金：国家自然科学基金项目(51822306)。

摘　　要：聚多巴胺(polydopamine,PDA)作为典型的黑色素类似物,拥有优异的生物相容性和抗氧化活性,这些独特的特性使PDA基纳米材料在炎症治疗、创面修复、仿生材料制备等领域受到广泛关注。尽管相关研究已经取得了很大的进展,但是PDA基纳米材料的抗氧化机制目前尚不明确。总结和讨论了PDA基纳米材料近几年在抗氧化方面的重要研究进展。在第一部分,简要介绍了PDA基纳米材料的合成及其抗氧化机制研究进展。在第二部分,主要从粒径、微观结构和氧化还原程度3个方面对其抗氧化性能的调控进行了总结。在第三部分,总结了PDA基纳米材料的抗氧化性能在生物医学领域的应用。最后,讨论了PDA基纳米材料面临的挑战及未来发展前景。希望能为基于PDA的抗氧化功能的材料的设计和开发提供思路与参考。Polydopamine(PDA), as the most typical melanin analog, possesses excellent antioxidant activity and biocompatibility. These unique properties make PDA-based nanomaterials widely concerned in the fields of inflammation treatment, wound repair and biomimetic material preparation. Although great progress has been made, the antioxidant mechanism of PDA-based nanomaterials remains unclear. In this review, we summarize and discuss the important research progress of PDA-based nanomaterials in anti-oxidation in recent years. In the first section, we introduce the synthesis and antioxidant mechanism of PDA-based nanomaterials. In the second section, we summarize the regulation of its antioxidant properties mainly from three aspects: particle size, microstructure and redox degree. In the third section, we summarize the antioxidant properties of PDA-based nanomaterials for biomedical applications. Finally, we discuss the challenges and future development prospects of PDA-based nanomaterials. We hope that this review can provide ideas and references for the design and development of PDA-based nanomaterials with antioxidant functions.

关 键 词：聚多巴胺 纳米材料 生物材料 抗氧化 炎症治疗 

分 类 号：TQ460.4[化学工程—制药化工] R318.08[医药卫生—生物医学工程]