水滑石纳米材料在生物医学领域中的研究进展  

Development of Hydrotalcite Nanomaterials in Biomedical Application

作　　者：吴捷[1] 王莉[1] 唐薇[1] 程亮[1] WU Jie;WANG Li;TANG Wei;CHENG Liang(Suzhou Nanotechnology Collaborative Innovation Center,Institute of Functional Nanotechnology and Soft Matter,Soochow University,Suzhou 215123,China)

机构地区：[1]苏州大学功能纳米与软物质研究院苏州纳米科技协同创新中心,江苏苏州215123

出　　处：《中国材料进展》2022年第9期749-757,共9页Materials China

基　　金：国家自然科学基金资助项目(U20A20254,52072253);江苏省自然科学杰出青年基金项目(BK20211544)。

摘　　要：在公众健康意识不断提高的背景下,二维纳米材料因其独特的各向异性和大的比表面积,已在各种生物医学应用中得到了广泛的探索。水滑石纳米材料即层状双氢氧化物(layered double hydroxides, LDHs)具有多种物理化学优势,包括优异的生物相容性、pH敏感的生物降解性、高度可调的化学成分和结构,并且易于与其他材料形成复合材料,在生物医学应用中显示出巨大的前景。总结了基于LDHs的纳米材料在生物医学应用方面的最新进展。首先讨论了LDHs基纳米材料的定义及其制备方法;然后系统地描述了LDHs在生物医学应用中的巨大潜力,重点从癌症治疗、抗菌、骨修复和生物传感等生物领域进行了全面的阐述;最后,在当前技术水平的基础上,对这个快速兴起的领域面临的挑战和未来发展战略做出了展望,期望能推动其让患者受益的生物医学应用。Against the backdrop of increasing public health awareness, two-dimensional nanomaterials have been extensively explored in various biomedical applications due to their unique anisotropy and large specific surface area properties. Layered double hydroxides(LDHs), also named hydrotalcite nanomaterials, have multiple physicochemical advantages, including excellent biocompatibility, pH-sensitive biodegradability, highly tunable chemical composition and structure, and easy to form composites with other materials, showing great promise in biomedical applications. In this review, we summarize recent advances in LDHs-based nanomaterials for biomedical applications. First, the material definition of LDHs-based nanomaterials and their preparation methods are discussed. We then systematically describe the great potential of LDHs for biomedical applications, focusing on comprehensive elaboration in biological fields such as cancer therapy, antibacterial, tissue engineering repair, and biosensing. Finally, building on the current state of the art, we provide insights into the challenges and future development strategies of this rapidly emerging field, which we expect to advance into biomedical applications that benefit patients.

关 键 词：水滑石 生物纳米材料 肿瘤治疗 抗菌 骨修复 

分 类 号：TB33[一般工业技术—材料科学与工程] TB383.1[医药卫生—生物医学工程] R318.08[医药卫生—基础医学]