2型糖尿病患者颈动脉内-中膜增厚的危险因素分析  

Risk factors for carotid artery intima-media thickness thickening in patients with type 2 diabetic mellitus

作　　者：刘海[1] 董雯丽 徐永权[1] 张艳琴 Liu Hai;Dong Wen-li;Xu Yong-quan;Zhang Yan-qin(Department of Internal Medicine,Gansu Rehabilitation Center Hospital,Lanzhou 730000,China)

机构地区：[1]甘肃省康复中心医院内科,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2022年第7期62-65,70,共5页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省重点研究发展计划资助项目(20YF3FA007)。

摘　　要：目的 探讨2型糖尿病患者颈动脉内-中膜厚度(IMT)增厚的危险因素,为临床预防提供参考。方法 选取甘肃省康复中心医院就诊的466例患者为研究对象,其中113例2型糖尿病,根据是否发生IMT增厚将2型糖尿病患者分为正常组、增厚组和斑块形成组,分析影响2型糖尿病患者IMT增厚的相关因素。结果 与正常组相比,增厚组患者的平均IMT、年龄、空腹血糖、C-反应蛋白、总胆固醇、低密度脂蛋白胆固醇、肌酐均显著偏高(P<0.05),是影响2型糖尿病患者发生IMT的相关因素;而同型半胱氨酸、尿酸、纤维蛋白原、甘油三酯、高密度脂蛋白胆固醇、尿素氮差异无统计学意义(P> 0.05)。。结论 年龄、空腹血糖、 C-反应蛋白、总胆固醇、低密度脂蛋白胆固醇、肌酐是影响2型糖尿病患者发生IMT增厚的相关因素,其中年龄是影响2型糖尿病患者发生IMT增厚的独立危险因素。Objective To explore the risk factors of carotid artery intima-media thickness(IMT) in patients with type 2 diabetes mellitus, so as to provide reference for clinical prevention. Methods A total of 466patients were selected from the Gansu Rehabilitation Center Hospital, including 113 cases of type 2 diabetes mellitus, who were divided into the normal group, the thickening group and the plaque formation group according to whether IMT occurred, and the relevant factors affecting IMT in type 2 diabetic population were analyzed. Results Compared with the normal group, the average IMT, age, fasting plasma glucose, C-reactive protein, total cholesterol, low-density lipoprotein cholesterol and creatinine were significantly higher in the thickening group(P < 0.05), which was a related factor affecting the occurrence of IMT in patients with type 2diabetes. There were no significant differences in homocysteine, uric acid, fibrinogen, triglycerides, highdensity lipoprotein cholesterol and urea nitrogen levels(P > 0.05). Conclusion Age, fasting plasma glucose,C-reactive protein, total cholesterol, low-density lipoprotein cholesterol and creatinine are related factors affecting the occurrence of IMT in patients with type 2 diabetes mellitus, and age is an independent risk factor in this respect.

关 键 词：2型糖尿病 颈动脉内-中膜 相关因素 

分 类 号：R587.1[医药卫生—内分泌]