p38丝裂原活化蛋白激酶信号通路在血管通路新内膜增生发生机制中的调控作用  

The regulatory role of p38 MAPK signaling pathway in the processes of neointimal hyperplasia in dialysis access vessels

作　　者：谢春贺 王保兴[1] XIE Chun-he;WANG Bao-xing(Department of Nephrology,The Third Hospital of Hebei Medical University,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学第三医院肾内科,石家庄050051

出　　处：《中国血液净化》2022年第8期588-591,共4页Chinese Journal of Blood Purification

摘　　要：p38丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路是介导细胞外信号到细胞内信号的重要信号转导系统之一,可调节细胞增殖、迁移、分化、基质沉积、炎症、凋亡等多种病理生理过程,其过度激活或表达减少会导致各种疾病的发生发展,包括血管新内膜增生介导的自体动静脉内瘘失功。p38 MAPK信号通路与血管新内膜增生有密切关系,新内膜增生是许多心血管疾病的主要形态特征,也是导致血管手术狭窄的原因,包括动静脉内瘘、旁路移植术和血管成形术,对患者健康、社会经济等各方面造成严重影响。基于p38 MAPK信号通路在血管新内膜增生中的作用,调控p38 MAPK信号通路可能成为治疗透析通路血管新内膜增生相关疾病的新靶点,对寻找新内膜增生新的治疗方式有重要意义。The p38 mitogen-activated protein kinase(MAPK)signaling pathway is one of the important signaling systems that mediates extracellular to intracellular signaling to regulate a variety of pathophysiological processes such as cell proliferation,migration,differentiation,matrix deposition,inflammation and apoptosis.Hyper-or hypoactivation of this signaling pathway may lead to the development of various diseases,including neointimal hyperplasia-mediated autogenous arteriovenous fistula dysfunction.The p38 MAPK signaling pathway is closely related to neointimal hyperplasia that causes many cardiovascular diseases as well as vascular stenosis after arteriovenous fistulas,bypass grafting and angioplasty operations,resulting in health problems of the patients and even social financial burdens.Based on the role of p38 MAPK signaling pathway in neointimal hyperplasia,modulation of this signaling pathway may be an alternative way for the treatment of neointimal hyperplasia-related diseases.

关 键 词：p38 MAPK信号通路 新内膜增生 血管平滑肌细胞 内皮细胞 

分 类 号：R318.16[医药卫生—生物医学工程]