美托洛尔联用小剂量胺碘酮对AMI伴室性心律失常患者心功能及预后的影响  

Effect of Metoprolol Combined with Low-dose Amiodarone on Cardiac Function and Prognosis of AMI Patients with Ventricular Arrhythmia

作　　者：顾小霞 张涛 闫振富 王丽君 赵智琛 GU Xiaoxia;ZHANG Tao;YAN Zhenfu;WANG Lijun;ZHAO Zhichen(ECG Room,Zhengzhou Central Hospital Afiliated to Zhengzhou University/Zhengzhou Central Hospital,Zhengzhou 450007,Henan,China;Department of Cardiology,Zhengzhou Central Hospital Afiliated to Zhengzhou University/Zhengzhou Central Hospital,Zhengzhou 450007,Henan,China)

机构地区：[1]郑州大学附属郑州中心医院/郑州市中心医院心肺功能科,河南郑州450007 [2]郑州大学附属郑州中心医院/郑州市中心医院心内科,河南郑州450007

出　　处：《中国药物滥用防治杂志》2022年第8期1106-1109,共4页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20191043)。

摘　　要：目的:探讨美托洛尔联用小剂量胺碘酮对急性心肌梗死(AMI)伴室性心律失常患者心功能及预后的影响。方法:选取2020年1月—2021年1月本院收治的88例AMI合并室性心律失常患者作为研究对象,根据随机数字表法分对照组及观察组,每组44例。对照组采取小剂量胺碘酮治疗,观察组在对照组基础上联用美托洛尔治疗,比较两组临床疗效、心功能、心肌损伤水平及预后。结果:观察组总有效率为93.18%,高于对照组的77.27%(P<0.05);两组治疗后LVEF、CO高于治疗前,且观察组低于对照组(P<0.05);两组治疗后CK-MB、NT-proBNP低于治疗前,且观察组低于对照组(P<0.05);两组不良反应及复发率比较,差异无统计学意义(P>0.05)。结论:AMI合并室性心律失常患者应用美托洛尔联用小剂量胺碘酮治疗可获确切疗效,可有效改善心功能,减少心肌损伤,且预后良好。Objective:To investigate the effect of metoprolol combined with low-dose amiodarone on cardiac function and prognosis in patients with acute myocardial infarction(AMI)with ventricular arrhythmia.Methods:A total of 88 patients with AMI combined with ventricular arrhythmia who were admitted to our hospital from January 2020 to January 2021 were selected as the research objects,and divided into the control group and the observation group according to the random number table method,with 44 cases in each group.The control group was treated with low-dose amiodarone,and the observation group was treated with metoprolol on the basis of the control group.The clinical efficacy,cardiac function,myocardial injury level and prognosis were compared between the two groups.Results:The total effective rate in the observation group was 93.18%,higher than 77.27%in the control group(P<0.05);LVEF and CO in the two groups after treatment were higher than those before treatment,and the observation group was lower than that in the control group(P<0.05);After treatment,CK-MB and NT-proBNP in the group were lower than those before treatment,and the observation group was lower than the control group(P<0.05).There was no significant difference in adverse reactions and recurrence rates between the two groups(P>0.05).Conclusion:Metoprolol combined with low-dose amiodarone in the treatment of AMI patients with ventricular arrhythmia can achieve definite curative effect,can effectively improve cardiac function,reduce myocardial damage,and has a good prognosis.

关 键 词：急性心肌梗死 室性心律失常 美托洛尔 胺碘酮 心功能 预后 

分 类 号：R541.7[医药卫生—心血管疾病] R542.22[医药卫生—内科学]