拉贝洛尔联合硫酸镁治疗妊娠期高血压的效果研究  

Effect of Labetalol Combined with Magnesium Sulfate in the Treatment of Gestational Hypertension

作　　者：王晴 刘子琳 刘洪宇 王爱华 WANG Qing;LIU Zilin;LIU Hongyu;ANG Aihua(Department of Obstetrics and Gynecology,the Second People's Hospital of Yucheng County,Shangqiu 476300,Henan,China;Department of Clinical Medicine,Henan University of Science and Technology,Luoyang 471003,Henan,China;Department of Obstetrics and Gynecology,Shangqiu City First People's Hospital,Shangqiu 476005,Henan,China)

机构地区：[1]虞城县第二人民医院妇产科,河南商丘476300 [2]河南科技大学临床医学部,河南洛阳471003 [3]商丘市第一人民医院妇产科,河南商丘476005

出　　处：《中国药物滥用防治杂志》2022年第8期1129-1132,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:研究拉贝洛尔联合硫酸镁治疗妊娠期高血压的临床效果。方法:选取2018年12月—2021年12月虞城县第二人民医院收治的妊娠期高血压患者80例作为研究对象,依据不同治疗方式划分成观察组(拉贝洛尔联合硫酸镁治疗)及对照组(硫酸镁治疗),各40例。比较两组临床疗效、血压水平、炎症指标水平、不良反应发生情况、妊娠不良事件发生率。结果:观察组治疗总有效率为95.00%,高于对照组的70.00%(P<0.05);观察组不良反应发生率及妊娠不良事件发生率低于对照组(P<0.05);观察组血清降钙素原、白介素18、白介素6、超敏C反应蛋白低于对照组(P<0.05);观察组舒张压、收缩压低于对照组(P<0.05)。结论:拉贝洛尔联合硫酸镁治疗妊娠期高血压患者的效果确切,可改善患者的炎性因子,控制血压水平,降低不良反应发生率及妊娠不良事件发生率,具有应用有效性及安全性。Objective:To study the clinical effect of labetalol combined with magnesium sulfate in the treatment of gestational hypertension.Methods:A total of 80 patients with gestational hypertension admitted to the Second People’s Hospital of Yucheng County from December 2018 to December 2021 were selected as subjects.According to different treatment methods,they were divided into observation group(labetalol combined with magnesium sulfate treatment)and control group(magnesium sulfate treatment),with 40 cases in each group.The clinical efficacy,blood pressure level,inflammatory index level,incidence of adverse reactions and incidence of adverse pregnancy events were compared between the two groups.Results:The total effective rate of the observation group was 95.00%,which was higher than 70.00%of the control group(P<0.05).The incidences of adverse reactions and adverse pregnancy events in the observation group were lower than those in the control group(P<0.05).Serum procalcitonin,interleukin 18,interleukin 6 and high-sensitivity C-reactive protein in the observation group were lower than those in the control group(P<0.05).The diastolic blood pressure and systolic blood pressure in the observation group were lower than those in the control group(P<0.05).Conclusion:The effect of labetalol combined with magnesium sulfate in the treatment of patients with gestational hypertension is exact,which can improve the inflammatory factors of patients,control the blood pressure level,and reduce the incidence of adverse reactions and adverse pregnancy events.It is effective and safe.

关 键 词：妊娠期高血压 拉贝洛尔 硫酸镁 妊娠不良事件 

分 类 号：R714.246[医药卫生—妇产科学]