高压氧配合间歇性低氧训练对脑梗死恢复期患者神经因子、认知功能及生活质量的影响  

The effect of Hyperbaric Oxygen and Intermittent Hypoxia Training on the Neurofactors, Cognitive Function and Quality of Life in Patients with Cerebral Infarction Recovery

作　　者：梁玲玲 LIANG Ling-ling(Department of Rehabilitation,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan,471000,China)

机构地区：[1]河南科技大学第一附属医院康复科,河南洛阳471000

出　　处：《黑龙江医学》2022年第17期2126-2128,共3页Heilongjiang Medical Journal

摘　　要：目的:探讨高压氧配合间歇性低氧训练对脑梗死恢复期患者神经因子、认知功能及生活质量的影响。方法:选取2019年3月—2019年12月河南科技大学第一附属医院收治的96脑梗死恢复期患者作为研究对象,并将其平均分为实验组和常规组,每组各48例。对常规组患者仅采取单纯高压氧治疗,而实验组患者则在前者基础上联合间歇性低氧训练治疗,评估并比较两组患者干预前后的神经因子、认知功能及生活质量等指标水平。结果:治疗前,两组患者神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)及S-100蛋白(S100B)等血清神经因子指标水平组间比较,差异无统计学意义(t=0.138、0.301、0.991,P>0.05);治疗后,实验组患者NSE、MBP及S100B等血清神经因子指标水平改善均优于常规组,差异有统计学意义(t=11.622、8.242、7.727,P<0.05);治疗前,两组患者MMSE、MBI评分组间比较,差异无统计学意义(t=0.279、0.224,P>0.05);治疗后,实验组MMSE、MBI评分均优于常规组,差异有统计学意义(t=4.012、7.362,P<0.05)。结论:高压氧配合间歇性低氧训练用于脑梗死恢复期治疗中,不仅有助于患者神经因子调节,同时还对患者认知功能及生活质量有积极改善作用。Objective: To explore the effects of hyperbaric oxygen combined with intermittent hypoxia training on neurofactors,cognitive function and quality of life of patients with cerebral infarction in convalescence. Methods: A total of 96 cerebral infarction convalescent patients admitted to the hospital from March 2019 to December 2019 were selected and divided into experimental group and routine group, with 48 cases in each group. The patients in the routine group were only treated with hyperbaric oxygen alone, while the patients in the experimental group were treated with intermittent hypoxia training on the basis of the former. The levels of nerve factors, cognitive function and quality of life before and after intervention were evaluated and compared between the two groups. Results: Before treatment, there was no statistically significant difference in the levels of serum neuronal factors such as neuron-specific enolase(NSE), myelin basic protein(MBP) and S-100 protein(S100B) between the two groups(t=0.138, 0.301,0.991, P>0.05). After treatment, the levels of NSE, MBP, S100B and other serum nerve factors in the experimental group were improved better than those in the conventional group, and the differences were statistically significant(t=11.622, 8.242, 7.727, P<0.05). Before treatment, there was no statistically significant difference in MMSE and MBI scores between the two groups(t=0.279,0.224, P>0.05). After treatment, the MMSE and MBI scores of the experimental group were better than those of the conventional group, and the difference was statistically significant(t=4.012,7.362, P<0.05). Conclusion: Hyperbaric oxygen combined with intermittent hypoxia training is used in the treatment of cerebral infarction in the recovery period, which not only helps to regulate the neurological factors of patients, but also positively improves the cognitive function and quality of life of patients.

关 键 词：高压氧 间歇性低氧训练 脑梗死恢复期 影响 

分 类 号：R459.6[医药卫生—治疗学]