托法替布联合云克针治疗类风湿关节炎的临床疗效观察分析  

Observation and Analysis of Clinical Curative Effect of Tofatibu Combined with Yunke Needle in Rheumatoid Arthritis

作　　者：姜克悦 JIANG Ke-yue(Department of Rheumatology and Immunology,Nanyang First People’s Hospital,Nanyang,Henan,473000,China)

机构地区：[1]南阳市第一人民医院风湿免疫科,河南南阳473000

出　　处：《黑龙江医学》2022年第18期2205-2207,共3页Heilongjiang Medical Journal

摘　　要：目的:观察托法替布联合云克针(99锝-亚甲基二膦酸盐注射液)治疗类风湿关节炎(RA)的疗效。方法:将2018年3月—2019年5月南阳市第一人民医院收治的70例RA患者作为研究对象,按就诊时间分为观察组和对照组,每组各35例。对照组使用常规疗法氨甲喋令针加上云克针治疗,观察组在对照组治疗基础上加用托法替布联合治疗。观察比较两组患者疗效、晨僵时间、关节症状、血清学指标[包括血清C-反应蛋白(CRP)、红细胞沉降率(ESR)、肿瘤坏死因子-α (TNF-α)、血管内皮生长因子(VEGF)]水平的差异以及不良反应发生情况。结果:观察组总有效率高于对照组,差异有统计学意义(χ^(2)=4.200,P<0.05);治疗后,观察组晨僵时间短、关节压痛数目、关节肿胀数目低于对照组,差异有统计学意义(t=2.560、4.652、4.722,P<0.05);治疗后,观察组患者的ESR、CRP、TNF-α以及VEGF水平均低于对照组,差异有统计学意义(t=3.393、2.031、7.448、4.495,P<0.05);两组患者不良反应发生率对比,差异无统计学意义(χ^(2)=0.764,P>0.05)。结论:托法替布联合云克针治疗RA临床疗效优于传统治疗方案,联合治疗可有效改善患者关节症状,降低调节机体炎症细胞因子表达,且不良反应较少,有较高的治疗安全性。Objective: To observe the curative effect of tofacitinib combined with Yunke needle(99technetium-methylene bisphosphonate injection) in the treatment of rheumatoid arthritis(RA). Methods: A total of 70 RA patients admitted to the hospital from March 2018 to May 2019 were selected as the research objects, and were divided into observation group and control group according to the visiting time, with 35 cases in each group. The control group was treated with conventional therapy methotrexate acupuncture plus Yunke acupuncture, and the observation group was treated with tofacitinib combined with the treatment of the control group. The curative effect, morning stiffness time, joint symptoms, serological index levels(including serum C-reactive protein [CRP], erythrocyte sedimentation rate [ESR], tumor necrosis factor-α [TNF-α], vascular endothelial growth factor(VEGF])and adverse reactions to treatment were compared between the two groups. Results: The curative effect of the observation group was higher than that of the control group, and the difference was statistically significant(χ2=4.200, P<0.05). After treatment,the morning stiffness time, the number of joint tenderness and the number of joint swelling in the observation group were lower than those in the control group, and the differences were statistically significant(t=2.560, 4.652, 4.722, P<0.05). After treatment,the levels of CRP, ESR, TNF-α and VEGF in the observation group were lower than those in the control group, and the differences were statistically significant(t=3.393, 2.031, 7.448, 4.495, P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups(χ2=0.764, P>0.05). Conclusion: The clinical efficacy of tofacitinib combined with Yunke acupuncture in the treatment of RA is better than that of traditional treatment, which can effectively improve joint symptoms,regulate the expression of inflammatory cytokines in the body, and have fewer adverse reactions and higher treatment safety.

关 键 词：托法替布 云克针 类风湿关节炎 疗效 

分 类 号：R593.22[医药卫生—内科学]