流感样病例中流感病毒阳性检出率的影响因素分析  

Analysis on Influencing Factors of Positive Detection Rate of Influenza Virus in Influenza-like Illness

作　　者：韩捷思 HAN Jie-si(Business Office of Tianjin Jizhou District Center for Disease Control and Prevention,Tianjin 301900,China)

机构地区：[1]天津市蓟州区疾病预防控制中心业务办公室,天津301900

出　　处：《医学信息》2022年第17期12-15,共4页Journal of Medical Information

摘　　要：目的 分析流感样病例中流感病毒阳性检出率的相关影响因素。方法 于全国流感监测网络系统中收集2018年1月-2020年12月采集的1815份流感样病例咽拭子样本,所有样本均采用实时荧光定量PCR(Real-time PCR)法完成核酸检测,统计其阳性检出率,并对其相关影响因素进行分析。结果 1815份流感样病例咽拭子样本的检测总阳性率为13.06%;流感样病例分年龄段阳性检出率由高到低依次为15~35岁、35岁及以上、14岁及以下;采样时间阳性检出率由高到低依次为第一季度、第四季度、第二季度、第三季度;发病、采样与送检的时间间隔时间越短,阳性检出率越高,差异有统计学意义(P<0.05);多因素Logistic回归分析显示,流感样病例年龄(OR=1.064,95%CI:0.968~1.354)、采样时间(OR=1.342,95%CI:0.975~1.659)、采样至送检时间(OR=1.476,95%CI:1.362~1.603)为流感阳性检出的危险因素。结论 流感样病例的年龄、采样时间、采样至送检时间可影响其流感阳性检出率。Objective To analyze the related influencing factors of positive detection rate of influenza virus in influenza-like illness.Methods Throat swab samples of 1815 influenza-like cases collected from January 2018 to December 2020 were collected from the national influenza surveillance network system.All samples were tested for nucleic acid by real-time fluorescence quantitative PCR(Real-time PCR).The positive detection rate was counted and its related influencing factors were analyzed.Results The total positive rate of 1815 throat swab samples was 13.06%.The positive detection rate of influenza-like illness in different age groups from high to low was 15-35 years old,35 years old and above,14 years old and below;the positive rate of sampling time from high to low was the first quarter,the fourth quarter,the second quarter,the third quarter;the shorter the time interval between onset,sampling and submission,the higher the positive detection rate,and the difference was statistically significant( P <0.05).Multivariate logistic regression analysis showed that age(OR=1.064,95%CI:0.968-1.354),sampling time(OR=1.342,95%CI:0.975-1.659) and time from sampling to submission(OR=1.476,95%CI:1.362-1.603) were risk factors for positive detection of influenza.Conclusion The age,sampling time and sampling to submission time of influenza-like illness can affect the positive detection rate of influenza.

关 键 词：流感病毒 咽拭子 阳性检出率 标本采集 采样时间 荧光定量PCR法 

分 类 号：R511.7[医药卫生—内科学]