H型高血压患者晨峰现象与早期肾损伤因子NGAL的关系  

The Relationship Between Morning Surge and Early Renal Injury Factor NGAL in Patients with H-type Hypertension

作　　者：张丹丹[1] 王义围[1] 谢云博 王娜[1] 张驰 ZHANG Dan-dan;WANG Yi-wei;XIE Yun-bo;WANG Na;ZHANG Chi(Department of General Medicine,Affiliated Hospital of Chengde Medical University,Chengde 067000,Hebei,China;Department of Neurology,Affiliated Hospital of Chengde Medical University,Chengde 067000,Hebei,China)

机构地区：[1]承德医学院附属医院全科医疗科,河北承德067000 [2]承德医学院附属医院神经内科,河北承德067000

出　　处：《医学信息》2022年第17期45-48,共4页Journal of Medical Information

基　　金：承德市科学技术研究与发展计划项目基金(编号:202006A073)。

摘　　要：目的 探讨H型高血压患者晨峰现象与早期肾损伤因子NGAL的关系。方法 选取承德医学院附属医院全科医疗科住院的224例H型高血压(Hcy≥10μmol/L)患者行24h动态血压监测(ABPM),按睡-谷晨峰值计算方法分组,>28 mm Hg为晨峰组(n=109),≤28 mmHg为非晨峰组(n=115),比较两组空腹血糖(FBG)、同型半胱氨酸(Hcy)、血脂、肌酐(Cr)、尿酸(UA)、尿素氮(BUN)、胱抑素C(CysC)、β_(2)微球蛋白(β_(2)-MG)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)。结果 晨峰组24h平均收缩压、白昼平均收缩压、夜间平均收缩压、收缩压晨峰、NGAL、CysC、β_(2)-MG高于非晨峰组(P<0.05);两组24h平均舒张压、白昼平均舒张压、夜间平均舒张压、舒张压晨峰、Cr、 BUN、UA比较,差异无统计学意义(P>0.05);Pearson相关分析显示NGAL与CysC、收缩压晨峰、β_(2)-MG、呈中、高度相关(r=0.581、0.516、0.759,P<0.05);与24h平均收缩压、FBG、Cr、呈低度相关(r=0.294、0.254、0.153,P<0.05),与BUN无相关(r=0.000,P>0.05)。结论 H型高血压患者收缩压晨峰是引起肾损伤的重要因素,NGAL是反映H型高血压早期肾损伤的重要指标。Objective To investigate the relationship between morning surge and NGAL in patients with H-type hypertension.Methods A total of 224 patients with H-type hypertension(Hcy≥10 μmol/L) who were hospitalized in the Department of General Medicine,Affiliated Hospital of Chengde Medical University were selected for 24-hour ambulatory blood pressure monitoring(ABPM).According to the calculation method of sleep-valley morning peak,>28 mmHg was the morning peak group(n=109),and ≤28 mmHg was the non-morning peak group(n=115).Fasting blood glucose(FBG),homocysteine(Hcy),blood lipids,creatinine(Cr),uric acid(UA),urea nitrogen(BUN),cystatin C(CysC),β_(2) microglobulin(β_(2)-MG),neutrophil gelatinase-associated lipocalin(NGAL) were compared between the two groups.Results The 24-hour mean systolic blood pressure,daytime mean systolic blood pressure,nighttime mean systolic blood pressure,morning systolic blood pressure surge,NGAL,CysC and β_(2)-MG in the morning peak group were higher than those in the non-morning peak group(P0.05).Pearson correlation analysis showed that NGAL was moderately and highly correlated with CysC,morning blood pressure surge and β_(2)-MG(r=0.581,0.516,0.759,P0.05).Conclusion Morning blood pressure surge is an important factor causing renal injury in patients with H-type hypertension,and NGAL is an important indicator of early renal injury in H-type hypertension.

关 键 词：H型高血压 晨峰现象 早期肾损伤 NGAL 

分 类 号：R544.1[医药卫生—心血管疾病] R692[医药卫生—内科学]