立体定向微创手术治疗脑胶质瘤的临床效果及对患者神经功能和日常生活能力的影响  

The Clinical Effect of Stereotactic Minimally Invasive Surgery in the Treatment of Patients with Glioma and its Influence on Nerve Function and Daily Living Ability

作　　者：许高权 XU Gao-quan(Department of Neurosurgery,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)

机构地区：[1]佳木斯市中心医院神经外科,黑龙江佳木斯154002

出　　处：《医学信息》2022年第17期76-78,共3页Journal of Medical Information

摘　　要：目的 评价立体定向微创手术治疗脑胶质瘤患者的临床效果及该术式对患者日常生活能力、神经功能的影响。方法 选取2017年10月-2020年9月在我院神经外科治疗的60例脑胶质瘤患者为研究对象,随机分为微创手术组和对照组,每组30例。对照组采用传统开颅手术治疗,微创手术组采用立体定向微创手术治疗。比较两组手术前、随访1年后脑脊液神经肽指标(精氨酸升压素与β-内啡肽)、日常活动能力量表评分、神经功能缺损程度量表评分、复发率及治疗总有效率。结果 微创手术组精氨酸升压素与β-内啡肽水平均高于对照组,差异有统计学意义(P<0.05);微创手术组复发率为0,低于对照组的20.00%,差异有统计学意义(P<0.05);微创手术组神经功能缺损程度量表评分低于对照组,日常活动能力量表评分高于对照组,差异有统计学意义(P<0.05);微创手术组总有效率为96.67%,高于对照组的76.67%,差异有统计学意义(P<0.05)。结论 立体定向微创手术治疗脑胶质瘤可改善患者脑脊液神经肽指标,提高临床疗效,降低复发率,有利于患者日常活动能力及神经功能恢复,值得应用。Objective To evaluate the clinical effect of stereotactic minimally invasive surgery in the treatment of glioma patients and its effect on daily living ability and neurological function.Methods From October 2017 to September 2020,60 patients with glioma treated in neurosurgery department of our hospital were randomly divided into minimally invasive surgery group and control group,with 30 cases in each group.The control group was treated with traditional craniotomy,and the minimally invasive surgery group was treated with stereotactic minimally invasive surgery.The cerebrospinal fluid neuropeptide indexes(arginine vasopressin and β-endorphin)before operation and 1 year after follow-up,daily activity scale score,neurological deficit scale score,recurrence rate and total effective rate of treatment were compared between the two groups.Results The levels of arginine vasopressin and β-endorphin in the minimally invasive surgery group were higher than those in the control group,and the differences were statistically significant(P <0.05).The recurrence rate of the minimally invasive surgery group was 0,which was lower than 20.00% of the control group,and the difference was statistically significant(P <0.05).The score of neurological deficit scale in the minimally invasive surgery group was lower than that in the control group,and the score of daily activity scale was higher than that in the control group,the difference was statistically significant(P<0.05).The total effective rate of the minimally invasive surgery group was 96.67%,which was higher than 76.67% of the control group,and the difference was statistically significant(P<0.05).Conclusion Stereotactic minimally invasive surgery in the treatment of glioma can improve the neuropeptide index of cerebrospinal fluid,improve the clinical efficacy,reduce the recurrence rate,and facilitate the recovery of patients’ daily activities and neurological function,which is worthy of application.

关 键 词：脑胶质瘤 微创手术 神经功能 日常活动能力 精氨酸升压素 Β-内啡肽 

分 类 号：R739.41[医药卫生—肿瘤]