支气管肺泡灌洗液病原学核酸检测在小婴儿喘息性肺部疾病的分布特点  

Distribution Characteristics of Pathogenic Nucleic Acid Detection of Bronchoalveolar Lavage Fluid in Asthmatic Lung Diseases of Infants

作　　者：田辉莲[1] 韩玉明[1] TIAN Hui-lian;HAN Yu-ming(Department of Pediatrics,the First People's Hospital of Kashgar,Kashgar 844000,Xinjiang,China)

机构地区：[1]喀什地区第一人民医院儿科,新疆喀什844000

出　　处：《医学信息》2022年第17期117-119,共3页Journal of Medical Information

基　　金：喀什地区科学研究与技术开发计划项目:支气管肺泡灌洗液病原体核酸检测在喀什地区婴幼儿肺部感染的临床研究(编号:KS2018042)。

摘　　要：目的 分析支气管肺泡灌洗液病原学核酸检测在小婴儿喘息性肺部疾病的分布特点。方法 收集2018年3月-2019年3月在我院诊治的124例小婴儿喘息性肺部疾病患儿临床资料,均进行支气管肺泡灌洗液病原学检验,分析病原体检出情况、不同年龄和不同病情病原学分布特点。结果 呼吸道合胞病毒检出率最高为30.64%,其次为人巨细胞病毒、肺炎克雷伯菌、肺炎链球菌、肺炎支原体、人肠道病毒、博卡病毒、人鼻病毒;0~6个月婴儿呼吸道合胞病毒、人巨细胞病毒、肺炎克雷伯菌、肺炎链球菌检出率均高于7~12个月婴儿,肺炎支原体、人肠道病毒检出率均低于7~12个月婴儿,差异有统计学意义(P<0.05);两组博卡病毒、人鼻病毒检出率比较,差异无统计学意义(P>0.05);重症患儿人巨细胞病毒、呼吸道合胞病毒、肺炎克雷伯菌检出率高于非重患儿,非重症患儿肺炎支原体、肺炎链球菌检出率高于重症患儿,差异有统计学意义(P<0.05);不同病情人肠道病毒、博卡病毒、人鼻病毒检出率比较,差异无统计学意义(P>0.05)。结论 小婴儿喘息性肺部疾病支气管肺泡灌洗液病原学核酸检测病原学主要为呼吸道合胞病毒,其次为人巨细胞病毒,再次为肺炎支原体、肺炎克雷伯菌、肺炎链球菌。Objective To analyze the distribution characteristics of bronchoalveolar lavage fluid nucleic acid detection in infants with asthmatic lung disease.Methods The clinical data of 124 infants with asthmatic lung disease diagnosed and treated in our hospital from March 2018 to March 2019were collected.The pathogenic test of bronchoalveolar lavage fluid was performed to analyze the pathogen detection and the pathogenic distribution characteristics of different ages and conditions.Results The highest detection rate of respiratory syncytial virus was 30.64%,followed by human cytomegalovirus,klebsiella pneumoniae,streptococcus pneumoniae,mycoplasma pneumoniae,human enterovirus,bocavirus and human rhinovirus.The detection rates of respiratory syncytial virus,human cytomegalovirus,klebsiella pneumoniae and streptococcus pneumoniae in infants aged 0-6 months were higher than those in infants aged 7-12 months,and the detection rates of mycoplasma pneumoniae and human enterovirus were lower than those in infants aged 7-12 months,the difference was statistically significant(P0.05).The detection rates of human cytomegalovirus,respiratory syncytial virus and klebsiella pneumoniae in the severe children were higher than those in the non-severe children,and the detection rates of mycoplasma pneumoniae and streptococcus pneumoniae in the non-severe children were higher than those in the severe children,the difference was statistically significant( P0.05).Conclusion Respiratory syncytial virus is the main pathogens of bronchoalveolar lavage fluid in infants with asthmatic pulmonary disease,followed by human cytomegalovirus,again for mycoplasma pneumoniae,klebsiella pneumoniae,streptococcus pneumoniae.

关 键 词：支气管肺泡灌洗液 病原学核酸检测 喘息性肺疾病 

分 类 号：R725.6[医药卫生—儿科]