国际垂体协会《库欣病的诊断和管理共识(更新版)》解读——药物篇  

Interpretation of Consensus on Diagnosis and Management of Cushing’s Disease:a Guideline Update from the Pituitary Society——Medical Therapies

作　　者：唐宇[1] 谭惠文[1,2] 李建薇[1,2] 余叶蓉[1,2] TANG Yu;TAN Huiwen;LI Jianwei;YU Yerong(Department of Endocrinology and Metabolism,West China Hospital,Sichuan University,Chengdu 610041,China;Medical Center of Pituitary Adenomas and Related Diseases,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院内分泌代谢科,四川省成都市610041 [2]四川大学华西医院垂体瘤及相关疾病诊疗中心,四川省成都市610041

出　　处：《中国全科医学》2022年第36期4483-4490,共8页Chinese General Practice

基　　金：四川大学华西医院学科卓越发展1·3·5工程临床研究孵化项目(2020HXFH034);四川省卫生健康委员会项目(20PJ046)。

摘　　要：库欣病是内源性库欣综合征最常见的病因,是垂体促肾上腺皮质激素腺瘤导致高皮质醇血症的临床综合征。由于高皮质醇血症的持续存在,库欣病患者可以出现满月脸、水牛背、向心性肥胖、代谢障碍等临床表现。对于库欣病,准确地诊断、恰当地治疗以及后续随访都极为重要。国际垂体协会根据新近研究证据,于2021年12月发布了《库欣病的诊断和管理共识(更新版)》,对于库欣病的筛查和诊断流程、术后监测、药物和放射治疗、并发症管理均有更新。本文重点对该共识中库欣病药物治疗部分进行解读,希望促进全科及专科医生对库欣病的规范化诊治。Cushing’s disease,the most common cause of endogenous Cushing’s syndrome,is hypercortisolemia caused by adrenocorticotropic hormone-secreting pituitary adenoma.Patients may present clinical symptoms such as moon face,buffalo back,central obesity and metabolic disorders due to the persistence of hypercortisolemia.Accurate diagnosis,appropriate treatment and follow-up of Cushing’s disease are vitally important.Based on recent evidence,the Pituitary Society published the Consensus on Diagnosis and Management of Cushing’s Disease:a Guideline Update in December 2021,with updates in screening and diagnosis procedures,postoperative monitoring,medical therapies and radiotherapy,and complication management.This article interprets the medical therapies recommended in the consensus,which will be helpful for general practitioners and specialists to standardize the diagnosis and treatment of Cushing’s disease.

关 键 词：库欣综合征 库欣病 诊疗指南 药物疗法管理 垂体协会 

分 类 号：R586.2[医药卫生—内分泌]