口服葡萄糖耐量试验中1小时血糖升高的意义研究进展  

A Review on the Significance of Elevated 1-hour Post-load Plasma Glucose during the Oral Glucose Tolerance Test

作　　者：黄雨澄 董爱梅[1,2,3] 黄有媛 费秀文[1,2] HUANG Yucheng;DONG Aimei;HUANG Youyuan;FEI Xiuwen(Department of General Practice,Peking University First Hospital,Beijing 100034,China;School of General Practice,Peking University Health Science Center,Beijing 100034,China;Department of Endocrinology,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院全科医学科,北京市100034 [2]北京大学医学部全科医学学系,北京市100034 [3]北京大学第一医院内分泌科,北京市100034

出　　处：《中国全科医学》2022年第35期4468-4472,共5页Chinese General Practice

基　　金：2020年度北京大学临床医学+X青年专项资助项目(PKU2020LCXQ026)——探索胰岛β细胞数量及功能在体无创评价方法。

摘　　要：口服葡萄糖耐量试验(OGTT)1 h血糖升高可能伴随胰岛素抵抗与胰岛β细胞功能障碍,与糖尿病及心血管疾病发生风险有关。本文综述了OGTT 1 h血糖升高的意义,相关研究显示10%~40%的糖耐量正常人群出现1 h血糖升高,在糖耐量受损(IGT)或空腹血糖受损(IFG)人群中比例更高。因此,临床应关注OGTT 1 h血糖,并在中国人群中明确用于糖尿病和糖尿病前期诊断的可能切点,将有助于早期诊断与干预。Elevated 1-hour post-load plasma glucose(1 hPG)concentration during the oral glucose tolerance test(OGTT)may be associated with insulin resistance and pancreaticβ-cell dysfunction,and higher risks of diabetes and cardiovascular disease.We reviewed the studies related to the significance of 1 hPG during the OGTT,in which 1 hPG during the OGTT has been reported to be prevalent in 10%to 40%of people with normal glucose tolerance,and the prevalence is higher in those with impaired glucose tolerance or impaired fasting glucose.Attention should be paid to the cutoff point of 1 hPG during the OGTT for the diagnosis of diabetes and pre-diabetes in Chinese population,which may be beneficial to early diagnosis and intervention of diabetes and pr-diabetes.

关 键 词：糖尿病 2型 葡糖耐量试验 葡糖耐受不良 餐后1小时血糖 糖尿病前期 

分 类 号：R587.1[医药卫生—内分泌]