冷冻胚胎移植激素替代周期治疗后单胎和双胎的新生儿结局:一项回顾性队列研究  

Neonatal outcomes of singletons and twins after hormone replacement therapy cycles in frozen embryo transfer:a retrospective cohort study

作　　者：陈峦峦 司徒冰[1,2] 李斯晨[3] 钟鑫琪[4] 王颖[5] 谭湘萍[5] 梅峥嵘[5] 林燕珊[3] CHEN Luan-luan;SI-TU Bing;LI Si-chen;ZHONG Xin-qi;WANG Ying;TAN Xiang-ping;MEI Zheng-rong;LIN Yan-shan(Clinical Research Management Office,The Third Affiliated Hospital of Guangzhou Medical University,Guangdong Guangzhou 510150,China;Guangdong Provincial Key Laboratory of Major Obstetric Diseases,The Third Affiliated Hospital of Guangzhou Medical University,Guangdong Guangzhou 510150,China;Center for Reproductive Medicine,The Third Affiliated Hospital of Guangzhou Medical University,Guangdong Guangzhou 510150,China;Department of Neonatology,The Third Affiliated Hospital of Guangzhou Medical University,Guangdong Guangzhou 510150,China;Department of Pharmacy,The Third Affiliated Hospital of Guangzhou Medical University,Guangdong Guangzhou 510150,China)

机构地区：[1]广州医科大学附属第三医院,临床研究管理办公室,广东广州510150 [2]广州医科大学附属第三医院,广东省产科重大疾病重点实验室,广东广州510150 [3]广州医科大学附属第三医院,生殖医学中心,广东广州510150 [4]广州医科大学附属第三医院,新生儿科,广东广州510150 [5]广州医科大学附属第三医院,药学部,广东广州510150

出　　处：《中国医院药学杂志》2022年第16期1653-1658,共6页Chinese Journal of Hospital Pharmacy

基　　金：广东省自然科学基金(编号:2018A030310188);广东省护理学会护理科研基金(编号:gdhlxueh2019zx129)。

摘　　要：目的:分析冻融胚胎移植(frozen embryo transfer,FET)患者激素替代周期(hormone replacement therapy,HRT)对单胎和双胎新生儿结局的影响。方法:收集广州医科大学附属第三医院生殖医学中心随访信息系统2009年1月至2019年12月FET患者接受HRT和自然周期(natural cycles,NC)内膜准备的新生儿信息,按单胎和双胎形成2个队列进行回顾性研究,分别以单因素和多因素Logistic回归分析探讨HRT和先天性畸形、早产、低出生体质量的相关性。结果:共纳入12989例新生儿,其中单胎新生儿HRT组4440例,NC组3543例;双胎新生儿HRT组2766例,NC组2240例。经多因素Logistic回归分析结果显示,HRT不是单胎先天性畸形(OR=0.84,95%CI:0.53~1.34)、早产(OR=0.97,95%CI:0.82~1.14)和低出生体质量(OR=0.98,95%CI:0.81~1.18)的独立影响因素(P>0.05)。HRT也不是双胎先天性畸形(0R=0.27,95%CI:0.06~1.26)、早产(OR=1.37,95%CI:0.87~2.15)和低出生体质量(OR=0.94,95%CI:0.80~1.11)的独立影响因素(P>0.05)。结论:FET患者HRT不影响单胎和双胎新生儿的先天性畸形、早产和低出生体质量发生。OBJECTIVE To analyze the effect of hormone replacement therapy(HRT)on the outcome of singleton and twin newborns in patients with frozen embryo transfer(FET).METHODS This retrospective cohort study collected information on neonates borned after frozen embryo transfer(FET)with HRT and natural cycles(NC)in the follow-up information system of The Third Affiliated Hospital of Guangzhou Medical University from January 2009 to December 2019.A retrospective study was conducted according to the two cohorts of singletons and twins.Univariate and multivariate logistic regression analysis were used to explore the correlation between HRT and congenital malformation,preterm birth and low birth weight.RESULTS A total of 12989 neonates were included.For singletons,there were 4440 cases in HRT group and 3543 cases in NC group.For twin neonates,there were 2766 cases in HRT group and 2240 cases in NC group.Multivariate logistic regression analysis showed HRT was not an independent factor for singleton congenital malformation(OR=0.84,95%CI:0.53-1.34),preterm birth(OR=0.97,95%CI:0.82-1.14),and low birth weight(OR=0.98,95%CI:0.81-1.18)(P>0.05).HRT was not an independent factor for twin congenital malformation(OR=0.27,95%CI:0.06-1.26),preterm birth(OR=1.37,95%CI:0.87-2.15),and low birth weight(OR=0.94,95%CI:0.80-1.11)(P>0.05).CONCLUSION HRT in FET patients did not affect the occurrence of congenital malformation,preterm birth as well as low birth weight in singleton and twin newborns.

关 键 词：激素替代周期 冻融胚胎移植 雌二醇 自然周期 先天性畸形 

分 类 号：R969.3[医药卫生—药理学]