脂肪来源间充质干细胞在自身免疫性疾病中的应用进展  

Advances in application of adipose-derived mesenchymal stem cells in autoimmunediseases

作　　者：李悦华 李青峰[1] 谢芸[1] LI Yuehua;LI Qingfeng;XIE Yun(Department of Plastic and Reconstructive Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院整复外科,上海200011

出　　处：《上海交通大学学报（医学版）》2022年第8期1131-1138,共8页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81701917);上海市教育委员会高峰高原学科建设计划(20191916)。

摘　　要：自身免疫性疾病(autoimmune diseases,AIDs)的发生发展是由于患者自身免疫耐受能力下降甚至被破坏,机体内部产生过多的自身抗体和(或)致敏性淋巴细胞,从而造成相关的组织病理变化和临床表型。目前临床上治疗该类疾病的主要方式仍是以药物为主的非特异性免疫抑制疗法,虽然在一定程度上可以缓解患者症状,但对于重症患者来说,效果往往不理想。近些年来,随着对间充质干细胞(mesenchymal stem cells,MSCs)的深入研究,人们对其特性的认识从具有高度自我更新与分化能力,逐渐扩展到免疫调节功能方面。与此同时,基于MSCs的研究方向也逐渐从最初的再生医学转向自身免疫学领域。随着大量相关的临床前和临床试验的开展,脂肪来源间充质干细胞(adipose-derived mesenchymal stem cells,AD-MSCs)的局部或全身应用被认为是临床上治疗自身免疫疾病的有效手段之一。该文就AD-MSCs的生物学特性及其在系统性红斑狼疮、类风湿关节炎、1型糖尿病、炎症性肠病、系统性硬化、银屑病等AIDs中的应用进行阐述并提出展望。The occurrence and development of autoimmune diseases is due to the decrease or even destruction of the patient's autoimmune tolerance,and excessive production of autoantibodies and/or sensitized lymphocytes in the body,resulting in histopathological changes and clinical phenotypes.At present,the main clinical treatment is the drug-based non-specific immunosuppression therapy.Although it can relieve some patients'symptoms,for severe patients,the effect is often not ideal.In recent years,with the in-depth study of mesenchymal stem cells(MSCs),people's understanding of their characteristics has gradually expanded from highly self-renewal and differentiation ability to immunomodulatory function.At the same time,the research direction based on MSCs has gradually shifted from regenerative medicine to the field of autoimmunology.With the development of preclinical and clinical trials,systemic or local application of adipose-derived mesenchymal stem cells(AD-MSCs)has been gradually recognized as one of the effective methods for clinical treatment of autoimmune diseases.In this review,the biological characteristics of AD-MSCs and their application to autoimmune diseases,including systemic lupus erythematosus,rheumatoid arthritis,type 1 diabetes mellitus,inflammatory bowel disease,systemic scleroderma,and psoriasis,are highlighted.

关 键 词：脂肪来源间充质干细胞(AD-MSCs) 免疫调节 自身免疫性疾病 临床应用 

分 类 号：R459.9[医药卫生—治疗学]