血清25-羟基维生素D与勃起功能障碍关系的研究  

The relationship between serum 25-hydroxy vitamin D and erectile dysfunction

作　　者：潘通[1] 黄永汉[1] 廖黎黎[1] 黄大雄 PAN Tong;HUANG Yonghan;LIAO Lili;HUANG Daxiong(The Reproductive Medicine Center,the First People′s Hospital of Foshan,Foshan 528000,Guangdong,China)

机构地区：[1]佛山市第一人民医院生殖医学中心,广东佛山528000

出　　处：《中国性科学》2022年第9期13-16,共4页Chinese Journal of Human Sexuality

基　　金：佛山市“十四五”医学高水平重点专科建设项目(FSGSP145020)。

摘　　要：目的 通过比较分析男性勃起功能障碍(ED)患者和勃起正常男性血清25-羟基维生素D[25(OH)D]水平的差异,探讨维生素D在诊疗ED中的临床应用价值。方法 选取2019年8月至2020年2月佛山市第一人民医院生殖医学中心诊治的65例初步诊断为ED的男性患者作为研究对象,设为试验组。另选取同期30名性功能正常的男性育前体检者作为对照组。比较两组的年龄、体重指数(BMI)、血清25(OH)D、空腹血糖、血清睾酮、雌二醇、泌乳素水平及国际勃起功能指数-5(IIEF-5)评分。结果 两组血清25(OH)D水平比较,差异具有统计学意义(P<0.05)。根据IIEF-5评分将试验组分为轻度组和中、重度组,两组血清25(OH)D水平比较,差异具有统计学意义(P<0.05)。ED患者IIEF-5评分与血清25(OH)D水平呈正相关(r=0.281,P<0.05)。结论 维生素D缺乏可能是ED发病和加重的潜在危险因素,血清25(OH)D检测对于ED患者的诊疗具有一定的临床应用价值。Objective To study the clinical value of vitamin D in the diagnosis and treatment of erectile dysfunction(ED) by analyzing the difference of serum 25-hydroxy vitamin D [25(OH) D] level between ED patients and normal men.Methods 65 ED patients(experimental group) and 30 men with normal erectile function(control group) admitted to the First People′s Hospital of Foshan from August 2019 to February 2020 were enrolled in the study.The age,body mass index,serum 25(OH)D,fasting blood glucose,serum testosterone,estradiol,prolactin levels and international index of erectile function-5(IIEF-5) score were compared between the two groups.Results There was significant difference in serum 25(OH)D level between the two groups(P<0.05).According to the IIEF-5 score,the experimental group was divided into mild group,and moderate and severe group,and the difference of serum 25(OH)D level between the two groups was statistically significant(P<0.05).IIEF-5 score was positively correlated with serum 25(OH)D level in ED patients(r=0.281,P<0.05).Conclusions Vitamin D deficiency may be a potential risk factor of ED.Serum 25(OH)D level may has a certain clinical value for the diagnosis and treatment of ED patients.

关 键 词：维生素D 25-羟基维生素D 勃起功能障碍 国际勃起功能指数-5 

分 类 号：R698[医药卫生—泌尿科学]