宫腔微生物的种类及与宫腔免疫细胞的相互调节  

Species of intrauterine microorganisms and their mutual regulation with intrauterine immune cells

作　　者：张婷婷[1] 唐妍[1] 何茜冬[1] 叶云 王晶晶 ZHANG Tinting;TANG Yan;HE Qiandong;YE Yun;WANG Jingjing(Reproductive Center,Zhongshan Hospital Affiliated to Sun Yat-sen University,Zhongshan 528400,Guangdong,China)

机构地区：[1]中山大学附属中山医院生殖中心,广东中山528400

出　　处：《中国性科学》2022年第9期103-106,共4页Chinese Journal of Human Sexuality

摘　　要：随着16SrRNA测序技术及宏基因组学的发展,正常宫腔内已被证实有微生物定植,但由于宫腔采样技术的受限及采样方式的不同,目前尚未确定一致的“健康”或“核心”子宫微生物群。与人体最大的微生物定植器官——肠道类似,宫腔内微生物的特异成分被免疫细胞表面的模式识别受体(PRRs),尤其是Toll-like受体(TLRs)所识别,从而动态调控免疫细胞的分化以维持宫腔内免疫平衡,其在维持菌群稳态、调节宫腔内免疫微环境、维持合适的妊娠免疫等方面均发挥了重要作用。本文就宫腔内微生物的种类、宫腔的免疫细胞、宫腔定植微生物与免疫细胞的相互调节等方面进行概述,旨在为探讨生殖器官相关病变及异常妊娠病因中的微生物因素提供新思路。With the development of 16 SrRNA sequencing technology and macrogenomics,microbial colonization has been confirmed in the normal uterine cavity.However,due to the limitation of uterine cavity sampling and different sampling methods,a consistent "healthy" or "core" uterine microbiota has not been determined at present.Similar to the intestinal tract,the largest microbial colonization organ in the human body,the specific components of microorganisms in uterine cavity are recognized by pattern recognition receptors(PRRs) on the surface of immune cells,especially Toll-like receptors(TLRs).They dynamically regulate the differentiation of immune cells,to maintain the immune balance in uterine cavity.They play an important role in maintaining the steady state of flora,regulating the immune microenvironment and maintaining appropriate pregnancy immunity.This paper summarizes the types of microorganisms and immune cells in the uterine cavity,and the mutual regulation between the two,in order to provide a new idea for exploring the microbial factors in the etiology of genital related diseases and abnormal pregnancy.

关 键 词：宫腔微生物 免疫细胞 Toll-like受体 

分 类 号：R711[医药卫生—妇产科学]