晚期糖基化终末产物对雌性繁殖性能的影响研究进展  

Research Progress on Advanced Glycation End Products in Female Fertility

作　　者：刘鸿宇 李俊[2] 颛清芮 杜幸柱 周丹 王龙飞 罗渝雯 傅祥伟[1,3] LIU Hongyu;LI Jun;ZHUAN Qingrui;DU Xingzhu;ZHOU Dan;WANG Longfei;LUO Yuwen;FU Xiangwei(College of Animal Science and Technology,China Agricultural University,Beijing 100193,China;Reproductive Medical Center,The First Hospital of Hebei Medical University,Hebei Shijiazhuang 050031,China;State Key Laboratory of Sheep Genetic Improvement and Healthy Production,Xinjiang Shihezi 832003,China)

机构地区：[1]中国农业大学动物科学技术学院,北京100193 [2]河北医科大学第一医院生殖中心,河北石家庄050031 [3]省部共建绵羊遗传改良与健康养殖国家重点实验室,新疆石河子832003

出　　处：《中国畜牧杂志》2022年第9期46-51,共6页Chinese Journal of Animal Science

基　　金：河北省自然科学基金精准医学联合基金培育项目(H2020206254);国家自然科学基金项目(32072736、81901562);中央高校基本科研业务费专项资金(2021TC061);河北医科大学第一医院“星火”青年科研项目(XH202005)。

摘　　要：晚期糖基化终末产物(Advanced Glycosylation End Products,AGEs)是动物体内的还原糖与蛋白质或脂质发生不可逆反应形成的一种共价加成物,它是非酶糖基化的最终产物。AGEs与糖脂代谢紊乱相关。AGEs可直接或通过AGEs-AGEs受体(Receptors For Advanced Glycation End Products,RAGE)等通路引发细胞损伤。近年来,AGEs对生育力的影响受到关注。AGEs可影响卵泡生长、卵母细胞质量、胚胎发育及着床,并对子代发育产生不良影响。通过减少AGEs摄入及阻断AGEs-RAGE结合可有效降低AGEs的负面作用。本文概述了AGEs的产生及作用途径,着重阐述了其对雌性繁殖性能的影响,揭示了抑制AGEs作用的治疗策略,以期为改善雌性繁殖性能提供新方法。Advanced glycosylation end products(AGEs)are covalent adducts formed by irreversible reactions of reducing sugars with proteins or lipids in animals,which are the end products of non-enzymatic glycosylation.AGEs are associated with disorders of glucolipid metabolism.Evidence has shown that AGEs would result in cell damage by disrupting protein function directly or through pathways like AGEs-RAGE(receptors for advanced glycation end products)pathway.Growing studies have focused on its effects on female fertility in recent years.It has been pointed out that AGEs can adversely affect follicle growth,oocyte quality as well as embryo development and implantation.In addition,AGEs would cause abnormalities in offspring development.Limiting AGEs intake and reducing AGEs-RAGE binding can effectively attenuate the negative effects of AGEs.In this paper,the formation and action pathway of AGEs were summarized.Moreover,the effects of AGEs on female fertility were mainly discussed,and the therapies for inhibiting AGEs action were proposed in order to provide new ways for improving female fertility.

关 键 词：晚期糖基化终末产物 糖脂代谢 雌性繁殖性能 

分 类 号：S814.1[农业科学—畜牧学]