江门市两条新型HIV-1 CRF55_01B/CRF07_BC重组体的基因组特征分析  

Genomic Characterization of Two Novel HIV-1 CRF55_01B/CRF07_BC Recombinants in Jiangmen,China

作　　者：李志菊 屈雅丽 关心 王立华[2] 张冬合[2] 胡贵方[1] LI Zhiju;QU Yali;GUAN Xin;WANG Lihua;ZHANG Donghe;HU Guifang(School of Public Health,Southern Medical University,Guangzhou 510515,China;Jiangmen Center for Disease Control and Prevention,Jiangmen 529030,China.)

机构地区：[1]南方医科大学公共卫生学院流行病学系,广州510515 [2]江门市疾病预防控制中心,江门529030

出　　处：《病毒学报》2022年第5期1150-1159,共10页Chinese Journal of Virology

基　　金：广东省省级科技计划项目(项目号:2014B020212007),题目:针对HIV P24抗原的艾滋病感染检测技术研究。

摘　　要：不同亚型和循环重组亚型(Circulating recombinant forms,CRFs)在同一人群中的传播往往导致独特重组型(Unique recombinant forms,URFs)的出现。在本研究中,我们发现了两条新的HIV-1 CRF55_01B/CRF07_BC第二代重组体(Second-generation recombinant forms,SGRs),它们分别来自江门市的同性恋和异性恋群体。系统进化分析表明,JM.pj44和JM.pj64的近全长基因组(Near full-length genomes,NFLGs)均以CRF55_01B为骨架,插入了CRF07_BC的基因片段,但断点位置不同。将本研究发现的两种新的NFLGs与其他研究中发现的CRF55_01B/CRF07_BC SGRs进行比较,目前未发现有相同的CRF55_01B/CRF07_BC重组体。The spread of diverse subtypes and circulating recombinant forms(CRFs)in the same population leads to the emergence of unique recombinant forms.We identified two novel human immunodeficiency virus(HIV)-1 CRF55_01B/CRF07_BC second-generation recombinant forms(SGRs),which were derived from homosexual and heterosexual groups,respectively,in Jiangmen(China).Phylogenetic analysis showed that the near-full-length genomes(NFLGs)of JM.pj44 and JM.pj64 were constructed by CRF55_01B backbones inserted with gene fragments of CRF07_BC,but differed in breakpoint positions.Notably,no evidence of identical CRF55_01B/CRF07_BC recombinants was found when these two new NFLGs were compared with CRF55_01B/CRF07_BC SGRs identified in other studies.

关 键 词：HIV-1 CRF55_01B/CRF07_BC 江门地区 重组体 

分 类 号：R373.9[医药卫生—病原生物学]