丹田降脂丸联合他汀类药物治疗高脂血症疗效与安全性的系统评价  

Systematic Review of Efficacy and Safety of Dantian Jiangzhi Pills Combined with Statins in the Treatment of Hyperlipidemia

作　　者：刘伟 李星星 范宗静[2] 崔杰[2] 吴旸[2] LIU Wei;LI Xingxing;FAN Zongjing;CUI Jie;WU Yang(Second School of Clinical Medicine,Beijing University of Chinese Medicine,Beijing 100078,China;Dept.of Cardiology,Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学第二临床医学院,北京100078 [2]北京中医药大学东方医院心血管科,北京100078

出　　处：《中国医院用药评价与分析》2022年第9期1134-1137,1141,共5页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:系统评价丹田降脂丸联合他汀类药物治疗高脂血症的疗效性与安全性。方法:通过检索中外数据库,纳入有关丹田降脂丸联合他汀类药物治疗高脂血症的临床随机对照试验(对照组患者给予他汀类药物,如阿托伐他汀、瑞舒伐他汀和辛伐他汀等;研究组患者在对照组基础上加用丹田降脂丸;剂量、疗程不限)。使用RevMan 5.3软件对数据进行统计分析。结果:共纳入9项随机对照试验,涉及1152例患者。分析结果显示,研究组患者的总有效率高于对照组(OR=3.38,95%CI=2.18~5.26,P<0.00001),血总胆固醇(MD=-0.89,95%CI=-1.34~-0.43,P=0.0002)、三酰甘油(MD=-0.66,95%CI=-1.03~-0.30,P=0.0003)、低密度脂蛋白胆固醇(MD=-0.61,95%CI=-0.97~-0.25,P=0.0009)和高密度脂蛋白胆固醇(MD=0.28,95%CI=0.16~0.41,P<0.00001)等指标水平改善程度优于对照组,上述差异均有统计学意义。研究组患者无明显不良反应。结论:丹田降脂丸联合他汀类药物用于高脂血症的治疗安全、有效。OBJECTIVE:To systematically evaluate the efficacy and safety of Dantian Jiangzhi pills combined with statins in the treatment of hyperlipidemia.METHODS:By searching Chinese and foreign databases,clinical randomized controlled trials of Dantian Jiangzhi pills combined with statins in the treatment of hyperlipidemia were included(the control group was given statins such as atorvastatin,resulvastatin and simvastatin;the study group received Dantian Jiangzhi pills based on the control group;the dose and duration of treatment were not limited).RevMan 5.3 was used to analyze the data of the included literature.RESULTS:Totally 9 randomized controlled trials were enrolled,including 1152 patients.The total effective rate of the study group was higher than that of the control group(OR=3.38,95%CI=2.18-5.26,P<0.00001),serum TC(MD=-0.89,95%CI=-1.34--0.43,P=0.0002)and TG(MD=-0.66,95%CI=-1.03--0.30,P=0.0003),LDL-C(MD=-0.61,95%CI=-0.97--0.25,P=0.0009)and HDL-C(MD=0.28,95%CI=0.16-0.41,P<0.00001)were better than those in the control group,and the differences were statistically significant.The study group had no obvious adverse drug reactions.CONCLUSIONS:Dantian Jiangzhi pills combined with statins are safe and effective in the treatment of hyperlipidemia.

关 键 词：丹田降脂丸 他汀类药物 高脂血症 META分析 

分 类 号：R932[医药卫生—生药学]