疏肝解郁汤治疗肝郁气滞型多囊卵巢综合征临床研究  

Clinical Study on Liver-Soothing and Depression-Relieving Decoction in the Treatment of Polycystic Ovary Syndrome with Liver Depression and Qi Stagnation

作　　者：张爱萍 侯玉华 吴琴玲 张荣荣 赵玉玲 刘立慧 张艳慧[2] ZHANG Ai-ping;HOU Yu-hua;WU Qin-ling;ZHANG Rong-rong;ZHAO Yu-ling;LIU Li-hui;ZHANG Yan-hui(Shenzhen Pingle Orthopedic and Traumatology Hospital,Shenzhen Pingshan Hospital of Traditional Chinese Medicine,Shenzhen,Guangdong,China,518001;Yellow River University of Science and Technology,Zhengzhou,Henan,China,450006)

机构地区：[1]深圳平乐骨伤科医院深圳市坪山区中医院,广东深圳518001 [2]黄河科技大学,河南郑州450006

出　　处：《河南中医》2022年第11期1700-1703,共4页Henan Traditional Chinese Medicine

基　　金：深圳市坪山区医疗卫生科研立项资助项目(201930)。

摘　　要：目的:观察疏肝解郁汤治疗肝郁气滞型多囊卵巢综合征(polycystic ovary syndrome,PCOS)的临床疗效。方法:将80例PCOS患者按照随机数字表法分为治疗组和对照组,每组各40例。对照组给予炔雌醇环丙孕酮片联合二甲双胍片,治疗组在对照组治疗的基础上服用疏肝解郁汤。比较两组患者治疗前后体质量指数(body mass index,BMI)、腰臀比(waist hip ratio,WHR)、胰岛素抵抗指数(homeostasis model assessment insulin resistance,HOMA-IR)变化情况。检测两组患者治疗前后促卵泡激素(follicle stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、睾酮(testosterone,T)及抗苗勒管激素(anti-mullerian hormone,AMH)水平。记录两组患者胁肋胀痛、善太息、急躁易怒、口干口苦、痤疮发生情况。结果:治疗组有效率为87.5%,对照组有效率为67.5%,两组有效率比较,差异具有统计学意义(P<0.05)。治疗组临床症状发生率均低于对照组,但仅有善太息及口干口苦症状发生率与对照组比较,差异具有统计学意义(P<0.05)。两组患者治疗BMI、HOMA-IR、FSH、LH、T、AMH水平低于本组治疗前,且治疗后治疗组低于对照组,差异具有统计学意义(P<0.05)。结论:疏肝解郁汤治疗肝郁气滞型PCOS,可改善患者临床症状,调节激素水平。Objective:To observe the clinical efficacy of Liver-Soothing and Depression-Relieving Decoction on Polycystic Ovary Syndrome(PCOS) with liver depression and qi stagnation.Methods:A total of 80 patients with PCOS were divided into the treatment group and the control group according to the method of random number table,with 40 cases in each group.The control group was given Ethinylestradiol Cyproterone Tablets combined with Metformin Tablets,while the treatment group was given Liver-Soothing and Depression-Relieving Decoction on the basis of the treatment of the control group.The changes of body mass index(BMI),waist-hip ratio(WHR) and homeostasis model assessment insulin resistance(HOMA-IR) were compared between the two groups before and after treatment.The levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T) and anti-mullerian hormone(AMH) were measured before and after treatment.The occurrence of flank and costal distension and pain,deep breathing,irritability,dry mouth,bitter mouth and acne in the two groups were recorded.Results:The effective rate of the treatment group was 87.5%,and that of the control group was 67.5%.The difference between the two groups was statistically significant(P<0.05).The incidence of clinical symptoms in the treatment group was lower than that in the control group,but only the incidence of symptoms of deep breathing,bitter mouth and dry mouth was significantly higher than that in the control group,and all the differences were statistically significant(P<0.05).BMI and HOMA-IR of the two groups were lower than those of the same group before treatment,and the above indexes of the treatment group were lower than those of the control group after treatment,and all the differences were statistically significant(P<0.05).The levels of FSH,LH,T and AMH in the two groups after treatment were lower than those of the same group before treatment,and the above levels in the treatment group were lower than those in the control group after treatment,and all the differen

关 键 词：多囊卵巢综合征 肝郁气滞证 疏肝解郁汤 中西医结合疗法 

分 类 号：R271.911.75[医药卫生—中西医结合]