Volatolomics in healthcare and its advanced detection technology  

作　　者：Wenwen Hu Weiwei Wu Yingying Jian Hossam Haick Guangjian Zhang Yun Qian Miaomiao Yuan Mingshui Yao 

机构地区：[1]School of Aerospace Science and Technology,Xidian University,Xi’an 730107,China [2]Interdisciplinary Research Center of Smart Sensors,School of Advanced Materials and Nanotechnology,Xidian University,Xi’an 730107,China [3]Faculty of Chemical Engineering and Russell Berrie Nanotechnology Institute,Technion-Israel Institute of Technology,Haifa 3200002,Israel [4]Department of Thoracic Surgery,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China [5]Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Clinical Research Center for Oral Diseases of Zhejiang Province Key Laboratory of Oral Biomedical Research of Zhejiang Province,Cancer Center of Zhejiang University,Hangzhou 310006,China [6]The Eighth Affiliated Hospital,Sun Yat-sen University,Shenzhen 518033,China [7]State Key Laboratory of Multi-phase Complex Systems,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 310006,China [8]Institute for Integrated Cell-Material Sciences,Kyoto University Institute for Advanced Study,Kyoto University,Kyoto 606-8501,Japan

出　　处：《Nano Research》2022年第9期8185-8213,共29页纳米研究（英文版）

基　　金：National Numerical Windtunnel Project(No.NNW2020ZT2-A21);Marie Sklodowska-Curie Actions:Individual Fellowship(No.H2020-MSCA-IF)[898486];Key Research and Development Program of Shaanxi(Nos.2022ZDLSF01-04 and 2020GXLH-Y-012);the National Natural Science Foundation of China(No.81972488);the Shenzhen Science and Technology Program(No.JCYJ20210324115209026).

摘　　要：Various diseases increasingly challenge the health status and life quality of human beings.Volatolome emitted from patients has been considered as a potential family of markers,volatolomics,for diagnosis/screening.There are two fundamental issues of volatolomics in healthcare.On one hand,the solid relationship between the volatolome and specific diseases needs to be clarified and verified.On the other hand,effective methods should be explored for the precise detection of volatolome.Several comprehensive review articles had been published in this field.However,a timely and systematical summary and elaboration is still desired.In this review article,the research methodology of volatolomics in healthcare is critically considered and given out,at first.Then,the sets of volatolome according to specific diseases through different body sources and the analytical instruments for their identifications are systematically summarized.Thirdly,the advanced electronic nose and photonic nose technologies for volatile organic compounds(VOCs)detection are well introduced.The existed obstacles and future perspectives are deeply thought and discussed.This article could give a good guidance to researchers in this interdisciplinary field,not only understanding the cutting-edge detection technologies for doctors(medicinal background),but also making reference to clarify the choice of aimed VOCs during the sensor research for chemists,materials scientists,electronics engineers,etc.

关 键 词：volatolomics electronic nose disease diagnosis SENSOR artificial olfaction volatile organic compounds 

分 类 号：TB383[一般工业技术—材料科学与工程]