重组人干扰素α2b喷雾剂治疗儿童流行性感冒的疗效及安全性评价  

Efficacy and safety evaluation of recombinant human interferonα2b spray in the treatment of influ-enza in children

作　　者：黎子武 梁林国 杨均秀 陈强锋 郑志坚 LI Ziwu;LIANG Linguo;YANG Junxiu;CHEN Qiangfeng;ZHENG Zhijian(Pediatric Internal Medicine Department,Foshan Fosun Chancheng Hospital Co.,LTD,Foshan 528000,China)

机构地区：[1]佛山复星禅诚医院有限公司儿内科,佛山528000

出　　处：《广州医药》2022年第5期76-79,共4页Guangzhou Medical Journal

摘　　要：目的探讨重组人干扰素α2b喷雾剂治疗儿童流行性感冒的疗效及安全性。方法选取我院2017年1月—2020年2月所收治的80例儿童流行性感冒患者,按1:1随机分为实验组及对照组,每组患儿40例,对照组患者给予奥司他韦治疗,实验组患者在对照组治疗基础上联合重组人干扰素α2b喷雾剂治疗,对比2组患者的疗效及安全性。结果实验组患儿咽痛症状消失时间(2.01±0.23)d、体温恢复正常时间(2.18±0.30)d、咳嗽症状消失时间(1.68±0.52)d、治疗时间(5.41±0.36)d均短于对照组(t=26.001、9.766、19.277、28.089,P<0.05);实验组患儿治疗有效率95.0%高于对照组治疗有效率(χ^(2)=4.114,P<0.05);实验组患儿的不良反应发生率低于对照组(χ^(2)=4.021,P<0.05)。结论重组人干扰素α2b喷雾剂治疗儿童流行性感冒的方案可获取较为理想的治疗效果,保证患儿用药安全性,尽快缓解患儿的临床症状,促使患儿病情康复,促进患儿健康生长,该治疗方案可在临床中推广应用。Objective To explore the efficacy and safety of recombinant human interferonα2b spray in the treatment of influenza in children.Methods Eighty children with influenza who were admitted to our hospital from January 2017 to February 2020 were randomly divided into experimental group and control group evenly,with 40 children in each group.Oseltamivir treatment was given to the control group,the experimental group was treated with recombinant human interferonα2b spray on the basis of oseltamivir,and the efficacy and safety of the two groups were compared.Results In the experimental group,the time for the disappearance of sore throat was(2.01±0.23)d,the time for the body temperature returned to normal was(2.18±0.30)d,the time for the cough to disappear was(1.68±0.52)d,and the treatment time was(5.41±0.36)d,which were all shorter than the control group(t=26.001,9.766,19.277,28.089,P<0.05).The treatment effective rate of children in the experimental group was 95.0%,which was significantly higher than that in the control group(χ^(2)=4.114,P<0.05);the incidence of adverse reactions in experimental group was significantly lower than that in the control group(χ^(2)=4.021,P<0.05).Conclusions The recombinant human interferonα2b spray for the treatment of influenza in children could obtain a more ideal therapeutic effect,ensure the safety of the children's medication,relieve the clinical symptoms as soon as possible,promote the improvement of the children's condition,and promote the healthy growth of the children.The treatment plan can be promoted and applied in clinical practice.

关 键 词：重组人干扰素α2b喷雾剂 儿童流行性感冒 疗效 安全性 

分 类 号：R725.6[医药卫生—儿科]