Interleukin-15 is a significant predictor of sarcopenia in human immunodeficiency virus infected patients on antiretroviral therapy:A cross-sectional study  

作　　者：Aprianta Agus Somia Agus Aryana Suka 

机构地区：[1]Internal Medicine Education Program,Faculty of Medicine,Udayana University,Denpasar,Bali,Indonesia [2]Tropical Infectious Disease Division,Department of Internal Medicine,Sanglah General Hospital,Denpasar,Bali,Indonesia [3]Geriatric Division,Department of Internal Medicine,Sanglah General Hospital,Denpasar,Bali,Indonesia

出　　处：《Asian Pacific Journal of Tropical Medicine》2022年第8期361-366,共6页亚太热带医药杂志（英文版）

摘　　要：Objective:To identify the relationship between interleukin(IL)-15 levels and sarcopenia in human immunodeficiency virus(HIV)-infected patients who have received antiretroviral therapy.Methods:This study was a cross-sectional design with 70 participants conducted from January to March 2021.All the participants were assessed for sarcopenia and the IL-15 levels.Sarcopenia was established based on the the Asian Working Group for Sarcopenia(AWGS)2019 criteria.Plasma IL-15 was determined.This analysis was carried out by means of 2×2 tabulation and the statistical test used is Chi-square.Results:Seventy patients received antiretroviral therapy>6 months and showed a good clinical response.Among them,36(51.4%)took zidovudine-based antiretroviral therapy with a median duration of illness of 5 years.The proportion of sarcopenia in patients with HIV infection was 32.9%.The median CD4 cell count was 395.5 cells/L(range:203-937 cells/L).Logistic regression analysis revealed that age>50 years(aOR 8.3,95%CI 1.6-44.5),underweight(aOR 7.7,95%CI 1.5-40.5),IL-15≥150.5 ng/L(aOR 4.9,95%CI 1.3-19.0)and female(aOR 4.8,95%CI 1.2-18.3 were significant and independent adverse predictors of sarcopenia in subjects with HIV infection.Conclusions:There is an association between high levels of IL-15 and sarcopenia in HIV-infected patients on antiretroviral therapy for more than 6 months with good clinical response.

关 键 词：Antiretroviral therapy HIV IL-15 Inflammatory SARCOPENIA UNDERWEIGHT 

分 类 号：R512.91[医药卫生—内科学]