人脐带间充质干细胞来源的外泌体在急性肾损伤治疗中的研究进展  

Advances in the treatment of acute kidney injury by exosoms derived from human umbilical cord mesenchymal stem cells

作　　者：袁圆 郭文文 王浩[2] 李灵玉 罗豪 魏华峰 吕兴华[2] Yuan Yuan;Guo Wen-wen;Wang Hao;Li Ling-yu;Luo Hao;Wei Hua-feng;LüXing-hua(The First School of Clinical Medicine,Lanzhou University,Lanzhou 730000,China;Day Surgery Center,The First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院日间手术中心,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2022年第9期66-70,共5页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省自然科学基金资助项目(20JR10RA700);兰州大学第一医院院内基金资助项目(ldyyyn2020-106)。

摘　　要：急性肾损伤(AKI)死亡率高,目前没有理想的临床治疗方案。间充质干细胞是目前基础研究和临床研究中最多的干细胞群体,在AKI治疗的相关研究中显示出良好的治疗潜力,其损伤修复功能很大程度上依赖于其旁分泌因子发挥的免疫调节作用,主要通过外泌体途径实现。在AKI的干细胞治疗过程中,外泌体参与调节病理生理过程,发挥损伤修复作用。本研究回顾并总结了关于人脐带间充质干细胞来源外泌体在AKI中的应用场景、基础实验及临床疗效,并探讨其具体作用机制及应用前景。Acute kidney disease(AKI)has a high mortality rate,and there is no ideal clinical treatment.Mesenchymal stem cells are the stem cell population most studied in basic and clinical studies,showing good therapeutic potential in the treatment of acute kidney injury.The damage repair function of mesenchymal stem cells is largely dependent on the immunomodulatory effect of paracrine factors,mainly through exosomes pathway.Exosomes are involved in the pathophysiological regulation of AKI during stem cell therapy,thus playing a role in injury repair.This paper reviewed and summarizeed the application scenarios,basic experiments and clinical efficacy of human umbilical cord mesenchymal stem cell-derived exosomein AKI,and discussed its specific mechanism and application prospects.

关 键 词：人脐带间充质干细胞 外泌体 急性肾损伤 再生医学 治疗机制 

分 类 号：R692[医药卫生—泌尿科学]