桔梗皂苷的药理作用研究进展  

Research progress on pharmacological effects of platycodin

作　　者：赵雨芯 谢龙[1] 李小芳[1] 施明毅[1] ZHAO Yu-xin;XIE Long;LI Xiao-fang;SHI Ming-yi(School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 61l137,Sichuan)

机构地区：[1]成都中医药大学药学院,四川成都611137

出　　处：《中药与临床》2022年第2期94-98,共5页Pharmacy and Clinics of Chinese Materia Medica

基　　金：四川省中医药管理局中医药科研专项(2020JC0038)。

摘　　要：桔梗来源于桔梗科植物桔梗的干燥根。在中医学中,具有宣肺,利咽,祛痰,排脓的功效,是中医临床上常用的化痰药,也是药食两用的中药之一。现代研究表明,桔梗的主要活性物质桔梗皂苷具有抗炎、抗氧化、降血脂、抗血栓、抗癌、调节免疫等多种药理作用。本文结合国内外文献报道,对桔梗皂苷的药理研究进行了综述,结合桔梗皂苷的药动学研究结果,及桔梗皂苷的应用进展,为桔梗皂苷的深入研究和利用提供参考依据。Jiegeng is derived from the dried roots of the Campanulacea plant Platycodon grandiflorum. In traditional Chinese medicine, it has the effects of dispersing lung, promoting pharynx, expelling phlegm and expelling pus, and is a commonly used phlegm-eliminating drug in the clinical practice of traditional Chinese medicine, as well as one of the traditional Chinese medicines with the dual-use of medicine and food. Modern studies have shown that platycodin, the main active substance of Jiegeng, has many pharmacological effects such as anti-inflammation, antioxidation, hypolipidemic, antithrombosis, anticancer and immune regulation. In this paper, the pharmacological and pharmacokinetic studies combined with the application progress of platycodin are reviewed by the combination of the literature reports at home and abroad, which provides a reference for its in-depth study and utilization.

关 键 词：桔梗皂苷 化痰药 药理作用 药动学 应用进展 

分 类 号：R285.5[医药卫生—中药学]