复方鲤鱼汤联合抗凝溶栓法治疗难治性肾病综合征的效果观察  

Effect Observation of Compound Carp Decoction Combined with Anticoagulant Thrombolytic Therapy in Treatment of Refractory Nephrotic Syndrome

作　　者：刘丙欣 刘秋霞 郝彩霞 Liu Bing-xin;Liu Qiu-xia;Hao Cai-xia(Qingdao Jingkang TCM Hospital of Nephrology,Qingdao 266000,Shandong Province,China;Qingdao Haici Medical Group,Qingdao 266000,Shandong Province,China)

机构地区：[1]青岛静康中医肾脏病医院,山东青岛266000 [2]青岛市海慈医疗集团,山东青岛266000

出　　处：《中国社区医师》2022年第26期52-54,共3页Chinese Community Doctors

摘　　要：目的:探讨复方鲤鱼汤联合抗凝溶栓法治疗难治性肾病综合征的效果。方法:选取2018年7月-2020年9月青岛静康中医肾脏病医院收治的难治性肾病综合征患者52例,所有患者在常规西药对症治疗基础上,采用复方鲤鱼汤联合抗凝溶栓法治疗,观察治疗前后患者体重、24 h尿量、尿蛋白定量(UTP)、血清白蛋白(ALB)、血清总胆固醇(TC)、血清甘油三酯(TG)的变化及凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)变化。结果:治疗后,患者体重低于治疗前,尿量多于治疗前,ALB水平高于治疗前,UTP水平低于治疗前,差异有统计学意义(P<0.05);治疗后,患者TC和TG水平均低于治疗前,差异有统计学意义(P<0.05);治疗后,患者PT及APTT水平与治疗前比较,差异无统计学意义(P>0.05)。结论:复方鲤鱼汤联合抗凝溶栓法治疗难治性肾病综合征能明显增加患者尿量,减轻水肿,可有效降低血脂及尿蛋白定量,提高血清白蛋白含量,疗效较为显著,且安全有效。Objective: To explore the therapeutic effect of Compound Carp Decoction combined with anticoagulant thrombolytic therapy in the treatment of refractory nephrotic syndrome. Methods: A total of 52 patients with refractory nephrotic syndrome who were treated in Qingdao Jingkang TCM Hospital of Nephrology from July 2018 to September 2020 were selected. On the basis of conventional western medicine symptomatic treatment, they were treated with Compound Carp Decoction combined with anticoagulant thrombolytic therapy. The patient’s body weight, 24-hour urine output, urine protein quantitation(UTP), serum albumin(ALB), serum total cholesterol(TC), serum triglyceride(TG) changes, as well as prothrombin time(PT) and activated partial thromboplastin time(APTT) changes before and after treatment were observed. Results: After treatment, the patient’s body weight was lower than that before treatment, the urine output was higher than that before treatment, the level of ALB was higher than that before treatment, and the level of UTP was lower than that before treatment, and the differences were statistically significant(P<0.05). After treatment, the levels of TC and TG in patients were lower than those before treatment, and the difference was statistically significant(P<0.05). There was no significant difference in PT and APTT levels before and after treatment(P>0.05). Conclusion: Compound Carp Decoction combined with anticoagulant thrombolytic therapy can significantly increase urine output and reduce edema in patients with refractory nephrotic syndrome. It can also effectively reduce blood lipids and urine protein quantitation, and increase serum albumin. The curative effect is significant, safe and effective.

关 键 词：鲤鱼汤 抗凝溶栓法 难治性肾病综合征 

分 类 号：R692[医药卫生—泌尿科学]